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dc.contributor.author
Pérez Lloret, Santiago
dc.contributor.author
Negre Pages, Laurence
dc.contributor.author
Damier, Philippe
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Delval, Arnaud
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Derkinderen, Paul
dc.contributor.author
Destée, Alain
dc.contributor.author
Meissner, Wassilios G.
dc.contributor.author
Tison, F.
dc.contributor.author
Rascol, Olivier
dc.date.available
2018-06-18T21:20:59Z
dc.date.issued
2017-12
dc.identifier.citation
Pérez Lloret, Santiago; Negre Pages, Laurence; Damier, Philippe; Delval, Arnaud; Derkinderen, Paul; et al.; L-DOPA-induced dyskinesias, motor fluctuations and health-related quality of life: the COPARK survey; Wiley Blackwell Publishing, Inc; European Journal of Neurology; 24; 12; 12-2017; 1532-1538
dc.identifier.issn
1351-5101
dc.identifier.uri
http://hdl.handle.net/11336/49186
dc.description.abstract
Background and purpose: Studies assessing the correlations between L-DOPA-induced dyskinesias (LIDs) and motor fluctuations with health-related quality of life (HRQoL) in Parkinson's disease (PD) have yielded conflicting results. This study aimed to assess the relationship between LIDs and motor fluctuations with HRQoL in patients with PD, and to assess the relative contribution of their severity and duration in a large sample of patients with PD. Methods: A total of 683 patients with PD from the COPARK survey were evaluated. HRQoL was assessed using the 39-Item Parkinson's Disease Questionnaire (PDQ-39) (primary outcome) and 36-Item Short Form Survey (SF-36). The daily duration and severity of LIDs were obtained from Unified Parkinson's Disease Rating Scale (UPDRS) IV items 32 and 33, respectively. The daily duration of motor fluctuations was obtained from UPDRS IV item 36 and severity was estimated as the difference between the UPDRS 2 (Activities of Daily Living) score in ‘OFF’ versus ‘ON’ condition. Results: A total of 235 patients with PD (35%) experienced motor fluctuations and 182 (27%) experienced LIDs. The PDQ-39 total and SF-36 physical scores were significantly worse in patients with LIDs, after adjusting for the presence of motor fluctuations. The PDQ-39 total score and SF-36 physical and mental score were significantly worse in patients with motor fluctuations, after adjusting for the presence of LIDs. The severity of LIDs and the duration of motor fluctuations significantly and independently affected PDQ-39 scores. The SF-36 physical score was affected only by the severity of motor fluctuations, whereas the mental score was not affected by any of the aforementioned variables. Conclusion: Our findings suggest that LIDs (mainly their severity) and motor fluctuations (mainly their duration) correlate independently with HRQoL in patients with PD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Health-Related Quality of Life
dc.subject
L-Dopa-Induced Dyskinesia
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Motor Complications
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Motor Fluctuations
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Parkinson'S Disease
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
L-DOPA-induced dyskinesias, motor fluctuations and health-related quality of life: the COPARK survey
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T15:11:54Z
dc.journal.volume
24
dc.journal.number
12
dc.journal.pagination
1532-1538
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.description.fil
Fil: Negre Pages, Laurence. LN Pharma; Francia. Hôpital la Colombière; Francia
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Fil: Damier, Philippe. Universite de Nantes; Francia
dc.description.fil
Fil: Delval, Arnaud. Universite Lille 3; Francia
dc.description.fil
Fil: Derkinderen, Paul. Universite de Nantes; Francia
dc.description.fil
Fil: Destée, Alain. Universite Lille 3; Francia
dc.description.fil
Fil: Meissner, Wassilios G.. Universite de Bordeaux; Francia
dc.description.fil
Fil: Tison, F.. Universite de Bordeaux; Francia
dc.description.fil
Fil: Rascol, Olivier. Université de Toulouse; Francia
dc.journal.title
European Journal of Neurology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13466
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/ene.13466
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