Artículo
Structural and Energetic Characterization of the Ankyrin Repeat Protein Family
Fecha de publicación:
12/2015
Editorial:
Public Library of Science
Revista:
Plos Computational Biology
ISSN:
1553-734X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Ankyrin repeat containing proteins are one of the most abundant solenoid folds. Usually implicated in specific protein-protein interactions, these proteins are readily amenable for design, with promising biotechnological and biomedical applications. Studying repeat protein families presents technical challenges due to the high sequence divergence among the repeating units. We developed and applied a systematic method to consistently identify and annotate the structural repetitions over the members of the complete Ankyrin Repeat Protein Family, with increased sensitivity over previous studies. We statistically characterized the number of repeats, the folding of the repeat-arrays, their structural variations, insertions and deletions. An energetic analysis of the local frustration patterns reveal the basic features underlying fold stability and its relation to the functional binding regions. We found a strong linear correlation between the conservation of the energetic features in the repeat arrays and their sequence variations, and discuss new insights into the organization and function of these ubiquitous proteins.
Palabras clave:
Ankyrin
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Parra, Rodrigo Gonzalo; Espada, Rocío; Verstraete, Nina; Ferreiro, Diego Ulises; Structural and Energetic Characterization of the Ankyrin Repeat Protein Family; Public Library of Science; Plos Computational Biology; 11; 12; 12-2015; 1-20
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