Artículo
Repeat proteins challenge the concept of structural domains
Espada, Rocío
; Parra, Rodrigo Gonzalo
; Sippl, Manfred; Mora, Thierry; Walczak, Aleksandra; Ferreiro, Diego
Fecha de publicación:
10/2015
Editorial:
Portland Press
Revista:
Biochemical Society Transactions
ISSN:
0300-5127
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Structural domains are believed to be modules within proteins that can fold and function independently. Some proteins show tandem repetitions of apparent modular structure that do not fold independently, but rather co-operate in stabilizing structural forms that comprise several repeat-units. For many natural repeat-proteins, it has been shown that weak energetic links between repeats lead to the breakdown of co-operativity and the appearance of folding sub-domains within an apparently regular repeat array. The quasi-1D architecture of repeat-proteins is crucial in detailing how the local energetic balances can modulate the folding dynamics of these proteins, which can be related to the physiological behaviour of these ubiquitous biological systems.
Palabras clave:
Ankyrin-Repeat
,
Local Frustration
,
Repeat-Protein
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Espada, Rocío; Parra, Rodrigo Gonzalo; Sippl, Manfred; Mora, Thierry; Walczak, Aleksandra; et al.; Repeat proteins challenge the concept of structural domains; Portland Press; Biochemical Society Transactions; 43; 5; 10-2015; 844-849
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