Production of Porous Scaffolds from Bioglass 45S5-derived Glasses

Abstract

Bioglass 45S5 has been successfully implemented in clinical applications, because of its capability of developing a strong bondwith the bone tissue. However, its low mechanical strength does not allow applying it in places that support load. In addition tothe high reactivity, an important requirement for its application is that the material must have a high porosity with pore sizesgreater than 100 microns, one of the key features tissue engineering materials. In a previous work, glass compositions derivedfrom Bioglass 45S5 were designed by means of natural minerals such as feldspar and quartz. Besides, leucite was developed as areinforcing phase after thermal treatment, getting good bioactivity results. The objective of this study is to evaluate the possibilityof producing porous scaffolds from such glasses. The foam replication technique is used to manufacture the scaffolds. Thermalevolutions of glasses are studied, so as to choose the best heat treatment schedule for the production of porous scaffolds. Texturalcharacteristics are evaluated.