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dc.contributor.author
Mastaglia, Silvina Rosana  
dc.contributor.author
Watson, Dana Zoe  
dc.contributor.author
Bellotti, Natalia  
dc.contributor.author
Fridman, Vanesa  
dc.contributor.author
Stecher, Daniel  
dc.contributor.author
Oliveri, María Beatriz  
dc.date.available
2018-06-18T14:59:50Z  
dc.date.issued
2017-03  
dc.identifier.citation
Mastaglia, Silvina Rosana; Watson, Dana Zoe; Bellotti, Natalia; Fridman, Vanesa; Stecher, Daniel; et al.; Vitamin D levels and their impact on mineral metabolism in HIV infected patients: An exploratory study; CIC Edizioni Internazionali; Clinical Cases in Mineral and Bone Metabolism; 14; 1; 3-2017; 18-22  
dc.identifier.issn
1971-3266  
dc.identifier.uri
http://hdl.handle.net/11336/48961  
dc.description.abstract
Vitamin D has immunomodulating properties. The nuclear receptor for vitamin D is expressed in several immune cells, which convert 25-hydroxyvitamin D(25OHD) to the active form 1,25 hydroxyvitamin D (1,25(OH)2 D). Under conditions of infection, 1,25(OH)2 D promotes production of cathelicidin (an antimicrobial peptide) in monocytes and activated macrophages. In vitro studies have shown the ability of cathelicidin to inhibit replication of human immunodeficiency virus (HIV-1) in T CD4 lymphocytes and macrophages. Objective: To evaluate vitamin D levels and their impact on mineral metabolism in HIV infected patients. Materials and Methods: Seventy-four clinical records of HIV/AIDS patients seen at the outpatients clinic were reviewed. The following data were collected: age, sex, time since diagnosis of HIV, HIV-1 viral load, CD4 counts (absolute value and percentage), and mineral metabolism determinations: 25OHD, intact parathormone (iPTH); serum calcium (sCa); serum phosphorus (sP) and serum crosslaps (sCTX). Vitamin D levels were stratified as follows: optimal: ≥30ng/ml; insufficient: 21-29ng/ml; moderately deficient: 20 -25OHD- >10 ng/ml and severely deficient ≤10 ng/ml. Results: Fifty-five clinical records were included; 82% of patients had 25OHD levels below 30ng/ml (insufficient: 23.6%, moderately deficient: 36.4%; and severely deficient: 21.8%). A significantly higher serum PTH levels in the moderately and severely deficient groups than in the optimal and insufficient groups was observed (p<0.05 and p<0.03 respectively). A weak negative correlation was observed between serum 25OHD and PTH levels (r=-0.268; p<0.004). Conclusion: Sub-optimal vitamin D levels are frequently observed in HIV/AIDS patients on antiretroviral therapy (ART). Systematic assessment of mineral metabolism is considered necessary in HIV/AIDS positive patients.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
CIC Edizioni Internazionali  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
25-Hydroxyvitamin D  
dc.subject
Hiv  
dc.subject
Mineral Metabolism  
dc.subject.classification
Salud Ocupacional  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Vitamin D levels and their impact on mineral metabolism in HIV infected patients: An exploratory study  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-05T20:13:41Z  
dc.journal.volume
14  
dc.journal.number
1  
dc.journal.pagination
18-22  
dc.journal.pais
Italia  
dc.journal.ciudad
Roma  
dc.description.fil
Fil: Mastaglia, Silvina Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina  
dc.description.fil
Fil: Watson, Dana Zoe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina  
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Fil: Bellotti, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina  
dc.description.fil
Fil: Fridman, Vanesa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina  
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Fil: Stecher, Daniel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina  
dc.description.fil
Fil: Oliveri, María Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina  
dc.journal.title
Clinical Cases in Mineral and Bone Metabolism  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.11138/ccmbm/2017.14.1.018  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ccmbm.com/common/php/portiere.php?ID=a2e901cb43d67a53c57687d4751d9ba2