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dc.contributor.author
Crespo, Rosana  
dc.contributor.author
Wei, K.  
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Rodenak Kladniew, Boris Emilio  
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Mercola, Mark  
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Ruiz Lozano, P.  
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Hurtado, C.  
dc.date.available
2018-06-15T20:55:30Z  
dc.date.issued
2017-01  
dc.identifier.citation
Crespo, Rosana; Wei, K.; Rodenak Kladniew, Boris Emilio; Mercola, Mark; Ruiz Lozano, P.; et al.; Effect of geraniol on rat cardiomyocytes and its potential use as a cardioprotective natural compound; Pergamon-Elsevier Science Ltd; Life Sciences; 172; 1-2017; 8-12  
dc.identifier.issn
0024-3205  
dc.identifier.uri
http://hdl.handle.net/11336/48873  
dc.description.abstract
Aims Reactive oxygen species (ROS) are generated in the ischaemic myocardium especially during early reperfusion and affect myocardial function and viability. Monoterpenes have been proposed to play beneficial roles in diverse physiological systems; however, the mechanisms of action remain largely unknown. This study aims to assess the effect of monoterpene geraniol (GOH) on neonatal rat ventricular cardiomyocytes (NRVCs) subjected to oxidative stress. Main methods We used an in vitro model of hypoxia-reoxygenation. Cardioprotective (AMPK) and cardiotoxic (ERK1/2, ROS) signaling indicators were measured. Assays were performed by fluorogenic probes, MTT assays and Western-blots. Key findings We determined that the addition of GOH (5–200�μM) to cultured normoxic and hypoxic-NRVCs diminished the endogenous production of ROS in stressed cardiomyocytes. We observed that GOH treatment increased pAMPK levels and decreased pERK1/2 levels in cultured NRVCs. Significance This report suggests that GOH is a candidate cardioprotective natural compound that operates by blunting the oxidative stress signaling that is normally induced by hypoxia-reoxygenation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Cardioprotection  
dc.subject
Geraniol  
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Neonatal Rat Cardiomyocytes  
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Oxidative Stress  
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Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Effect of geraniol on rat cardiomyocytes and its potential use as a cardioprotective natural compound  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-15T18:34:36Z  
dc.journal.volume
172  
dc.journal.pagination
8-12  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Crespo, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina  
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Fil: Wei, K.. Tongji University; China  
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Fil: Rodenak Kladniew, Boris Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina  
dc.description.fil
Fil: Mercola, Mark. Stanford Cardiovascular Institute; Estados Unidos. Sanford Burnham Prebys Medical Discovery Institute; Estados Unidos  
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Fil: Ruiz Lozano, P.. Sanford Burnham Prebys Medical Discovery Institute; Estados Unidos. Stanford Cardiovascular Institute; Estados Unidos  
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Fil: Hurtado, C.. Stanford Cardiovascular Institute; Estados Unidos  
dc.journal.title
Life Sciences  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.lfs.2017.01.008  
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info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0024320517300310