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dc.contributor.author
Neukam, K.
dc.contributor.author
Ridruejo, Ezequiel
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dc.contributor.author
Pérez, Paula Soledad
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dc.contributor.author
Campos, Rodolfo Hector
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dc.contributor.author
Martínez, A. P.
dc.contributor.author
Di Lello, Federico Alejandro
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dc.date.available
2018-06-15T17:47:51Z
dc.date.issued
2018-02
dc.identifier.citation
Neukam, K.; Ridruejo, Ezequiel; Pérez, Paula Soledad; Campos, Rodolfo Hector; Martínez, A. P.; et al.; Prevalence of hepatitis C virus infection according to the year of birth: identification of risk groups; Springer; European Journal of Clinical Microbiology; 37; 2; 2-2018; 247-254
dc.identifier.issn
0934-9723
dc.identifier.uri
http://hdl.handle.net/11336/48819
dc.description.abstract
Hepatitis C virus (HCV) screening according to the year of birth is recommended is some countries based on epidemiological data. The aim of this study was to analyze anti-HCV prevalence among people born between 1905 and 2015 in Argentina. Patients attending a tertiary care hospital in Buenos Aires, Argentina, from 2001 to 2015, who had a determination of anti-HCV, were included. Of 22,079 patients analyzed, 1,152 (5.2%; 95% confidence interval [CI]: 4.9%–5.5%) patients showed positive anti-HCV and 729 (3.3%; 95% CI: 3.1%–3.5%) patients showed detectable viremia. Three risk groups were identified (HCV prevalence): low-risk group—outpatient clinics/emergencies (2.8%); intermediate-risk group—in-patients (8%); and high-risk group—dialysis/transplants (27.2%). In the low-risk group, being born in 1973 or before was identified as a cut-off value for the risk of anti-HCV acquisition (area under the receiver-operator characteristic curve: 75.1 [95% asymptotic CI: 0.732–0.770; p < 0.001]). Ninety-one patients born after 1973 (0.8%) showed positive anti-HCV versus 457 individuals born in 1973 or before (5.8%), p < 0.001. In this group, positive anti-HCV was observed in 252 females (2.1%) and 296 males (4.1%), p < 0.001. In a multivariate analysis adjusted for gender, alanine-aminotransferase levels and HIV coinfection, being born in 1973 or before was independently identified as a risk for positive anti-HCV (adjusted odds ratio: 14.234 [95% CI: 9.993–20.277]; p < 0.001). People born in 1973 or before without other risk factors should be included in screening programs to link the highest possible number of HCV-infected patients to appropriate care and treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hepatitis C Virus
dc.subject
Patient Management
dc.subject
Prevalence
dc.subject
Screening Programs
dc.subject
Year of Birth
dc.subject.classification
Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Prevalence of hepatitis C virus infection according to the year of birth: identification of risk groups
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T15:08:01Z
dc.journal.volume
37
dc.journal.number
2
dc.journal.pagination
247-254
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Neukam, K.. Consejo Superior de Investigaciones Científicas; España. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
dc.description.fil
Fil: Pérez, Paula Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Campos, Rodolfo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Martínez, A. P.. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
dc.description.fil
Fil: Di Lello, Federico Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
European Journal of Clinical Microbiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10096-017-3123-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10096-017-3123-4
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