Mostrar el registro sencillo del ítem
dc.contributor.author
Majerowicz, David
dc.contributor.author
Calderón Fernández, Gustavo Mario
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Alves Bezerra, Michelle
dc.contributor.author
De Paula, Iron F.
dc.contributor.author
Cardoso, Livia S.
dc.contributor.author
Juarez, Marta Patricia
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Atella, Georgia C.
dc.contributor.author
Gondim, Katia C.
dc.date.available
2018-06-15T17:30:50Z
dc.date.issued
2016-10
dc.identifier.citation
Majerowicz, David; Calderón Fernández, Gustavo Mario; Alves Bezerra, Michelle; De Paula, Iron F.; Cardoso, Livia S.; et al.; Lipid metabolism in Rhodnius prolixus: Lessons from the genome; Elsevier Science; Gene; 596; 10-2016; 27-44
dc.identifier.issn
0378-1119
dc.identifier.uri
http://hdl.handle.net/11336/48813
dc.description.abstract
The kissing bug Rhodnius prolixus is both an important vector of Chagas? disease and an interesting model for investigation into the field of physiology, including lipid metabolism. The publication of this insect genome will bring a huge amount of new molecular biology data to be used in future experiments. Although this work represents a promising scenario, a preliminary analysis of the sequence data is necessary to identify and annotate the genes involved in lipid metabolism. Here, we used bioinformatics tools and gene expression analysis to explore genes from different genes families and pathways, including genes for fat breakdown, as lipases and phospholipases, and enzymes from β-oxidation, fatty acid metabolism, and acyl-CoA and glycerolipid synthesis. The R. prolixus genome encodes 31 putative lipase genes, including 21 neutral lipases and 5 acid lipases. The expression profiles of some of these genes were analyzed. We were able to identify nine phospholipase A2 genes. A variety of gene families that participate in fatty acid synthesis and modification were studied, including fatty acid synthase, elongase, desaturase and reductase. Concerning the synthesis of glycerolipids, we found a second isoform of glycerol-3-phosphate acyltransferase that was ubiquitously expressed throughout the organs. Finally, all genes involved in fatty acid β-oxidation were identified, but not a long-chain acyl-CoA dehydrogenase. These results provide fundamental data to be used in future research on insect lipid metabolism and its possible relevance to Chagas? disease transmission.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Insect Physiology
dc.subject
Metabolic Pathway
dc.subject
Bioinformatics
dc.subject
Rt-Qpcr
dc.subject
Lipid Biosynthesis
dc.subject
Gene Family
dc.subject.classification
Otras Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Lipid metabolism in Rhodnius prolixus: Lessons from the genome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-14T19:05:36Z
dc.journal.volume
596
dc.journal.pagination
27-44
dc.journal.pais
Países Bajos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Majerowicz, David. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil
Fil: Calderón Fernández, Gustavo Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
dc.description.fil
Fil: Alves Bezerra, Michelle. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil
Fil: De Paula, Iron F.. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil
Fil: Cardoso, Livia S.. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil
Fil: Juarez, Marta Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
dc.description.fil
Fil: Atella, Georgia C.. Universidade Federal do Rio de Janeiro; Brasil. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular; Brasil
dc.description.fil
Fil: Gondim, Katia C.. Universidade Federal do Rio de Janeiro; Brasil
dc.journal.title
Gene
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378111916307831
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.gene.2016.09.045
Archivos asociados