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dc.contributor.author
Cardinali, Daniel Pedro
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dc.contributor.author
Vigo, Daniel Eduardo
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dc.date.available
2018-06-15T17:24:05Z
dc.date.issued
2017-11
dc.identifier.citation
Cardinali, Daniel Pedro; Vigo, Daniel Eduardo; Melatonin, mitochondria, and the metabolic syndrome; Springer International; Cellular and Molecular Life Sciences; 74; 21; 11-2017; 3941-3954
dc.identifier.issn
1420-682X
dc.identifier.uri
http://hdl.handle.net/11336/48805
dc.description.abstract
A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. As a chronobiotic/cytoprotective agent, melatonin has a special place in prevention and treatment of MS. Melatonin levels are reduced in diseases associated with insulin resistance like MS. Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, partly for its role as a metabolic regulator and mitochondrial protector. We discuss in the present review the several cytoprotective melatonin actions that attenuate inflammatory responses in MS. The clinical data that support the potential therapeutical value of melatonin in human MS are reviewed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aging
dc.subject
Diabetes
dc.subject
Inflammation
dc.subject
Insulin Signaling
dc.subject
Melatonin
dc.subject
Metabolic Syndrome
dc.subject
Mitochondria
dc.subject
Obesity
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Melatonin, mitochondria, and the metabolic syndrome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T15:07:48Z
dc.identifier.eissn
1420-9071
dc.journal.volume
74
dc.journal.number
21
dc.journal.pagination
3941-3954
dc.journal.pais
Suiza
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dc.journal.ciudad
Basilea
dc.description.fil
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
Cellular and Molecular Life Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007%2Fs00018-017-2611-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00018-017-2611-0
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