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Artículo

A derivative UV spectrophotometry method for the determination of levothyroxine sodium in tablets

Gregorini, Anabella; Ruiz, María EsperanzaIcon ; Volonté, Maria Guillermina
Fecha de publicación: 06/2013
Editorial: SP MAIK Nauka/Interperiodica
Revista: Journal Of Analytical Chemistry
ISSN: 1061-9348
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Analítica

Resumen

A derivative UV (DUV) spectrophotometric method was developed for the determination of Levothyroxine Sodium (LT4) in tablets of different doses. Quantification was performed using the second derivative of the absorption spectrum at 253 nm (2D253) in methanol : water (50 : 50; v/v) (pH 11.2). The method was validated and compared with an HPLC procedure carried out using a RP18 column (125 x~ 4 mm, 5 microm) and methanol: phosphoric acid (0.1%) (70 : 30, v/v) (pH 3) as mobile phase. Flow rate was set at 1.5 mL/min, and detection was performed at 225 nm. The proposed DUV method was linear in the range 3.0 - 40.0 microg/mL with an appropriate precision and accuracy, and it was selective for the drug under study. On the other hand, results obtained by 2D253 analysis were similar to those obtained by HPLC, with no statistically significant differences between them. Therefore, it was concluded that the developed method is suitable for the determination of LT4 in tablets at the tested doses.
Palabras clave: Levothyroxine Sodium , Derivative Uv Spectrophotometry , High Performance Liquid Chromatography
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/4880
URL: http://link.springer.com/article/10.1134/S1061934813060075
DOI: http://dx.doi.org/10.1134/S1061934813060075
DOI: http://dx.doi.org/ 10.1134/S1061934813060075
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos(CINDECA)
Articulos de CENTRO DE INV EN CS.APLICADAS "DR.JORGE J.RONCO"
Citación
Gregorini, Anabella; Ruiz, María Esperanza; Volonté, Maria Guillermina; A derivative UV spectrophotometry method for the determination of levothyroxine sodium in tablets; SP MAIK Nauka/Interperiodica; Journal Of Analytical Chemistry; 68; 6; 6-2013; 510-515
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