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dc.contributor.author
Ravindranath, Vijayalakshmi
dc.contributor.author
Dang, Hoang Minh
dc.contributor.author
Goya, Rodolfo Gustavo
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dc.contributor.author
Mansour, Hader
dc.contributor.author
Nimgaonkar, Vishwajit L.
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Russell, Vivienne Ann
dc.contributor.author
Xin, Yu
dc.date.available
2018-06-15T17:19:22Z
dc.date.issued
2015-11
dc.identifier.citation
Ravindranath, Vijayalakshmi; Dang, Hoang Minh; Goya, Rodolfo Gustavo; Mansour, Hader; Nimgaonkar, Vishwajit L.; et al.; Regional research priorities in brain and nervous system disorders; Nature Publishing Group; Nature; 527; 7578; 11-2015; E198-E206
dc.identifier.issn
0028-0836
dc.identifier.uri
http://hdl.handle.net/11336/48799
dc.description.abstract
The characteristics of neurological, psychiatric, developmental and substance-use disorders in low-and middle-income countries are unique and the burden that they have will be different from country to country. Many of the differences are explained by the wide variation in population demographics and size, poverty, conflict, culture, land area and quality, and genetics. Neurological, psychiatric, developmental and substance-use disorders that result from, or are worsened by, a lack of adequate nutrition and infectious disease still afflict much of sub-Saharan Africa, although disorders related to increasing longevity, such as stroke, are on the rise. In the Middle East and North Africa, major depressive disorders and post-traumatic stress disorder are a primary concern because of the conflict-ridden environment. Consanguinity is a serious concern that leads to the high prevalence of recessive disorders in the Middle East and North Africa and possibly other regions. The burden of these disorders in Latin American and Asian countries largely surrounds stroke and vascular disease, dementia and lifestyle factors that are influenced by genetics. Although much knowledge has been gained over the past 10 years, the epidemiology of the conditions in low-and middle-income countries still needs more research. Prevention and treatments could be better informed with more longitudinal studies of risk factors. Challenges and opportunities for ameliorating nervous-system disorders can benefit from both local and regional research collaborations. The lack of resources and infrastructure for health-care and related research, both in terms of personnel and equipment, along with the stigma associated with the physical or behavioural manifestations of some disorders have hampered progress in understanding the disease burden and improving brain health. Individual countries, and regions within countries, have specific needs in terms of research priorities.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nervous Disorders
dc.subject
Brain
dc.subject
Research Priorities
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Regional research priorities in brain and nervous system disorders
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-14T19:05:30Z
dc.journal.volume
527
dc.journal.number
7578
dc.journal.pagination
E198-E206
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Ravindranath, Vijayalakshmi. Indian Institute of Science; India
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Fil: Dang, Hoang Minh. Vietnam National University; Vietnam
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Fil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
dc.description.fil
Fil: Mansour, Hader. University of Pittsburgh; Estados Unidos. Mansoura University; Egipto
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Fil: Nimgaonkar, Vishwajit L.. University of Pittsburgh; Estados Unidos
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Fil: Russell, Vivienne Ann. University of Cape Town; Sudáfrica
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Fil: Xin, Yu. Peking University; China
dc.journal.title
Nature
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1038/nature16036
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nature16036
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