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Artículo

Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson's and Huntington's disease

Birba, AgustinaIcon ; García, Adolfo MartínIcon ; Kozono, Giselle; Legaz, AgustinaIcon ; Ibañez, Agustin MarianoIcon ; Sedeño, LucasIcon ; García, Adolfo MartínIcon
Fecha de publicación: 09/2017
Editorial: Pergamon-Elsevier Science Ltd
Revista: Neuroscience and Biobehavioral Reviews
ISSN: 0149-7634
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Estudios Generales del Lenguaje; Psicología

Resumen

Within the language domain, movement disorders triggered by frontostriatal damage are characterized by deficits in action verbs, motor-language coupling, and syntax. However, these impairments have not been jointly interpreted under a unifying rationale or integratively assessed in terms of possible clinical implications. To bridge these gaps, here we introduce the “disrupted motor grounding hypothesis”, a new framework to conceive such impairments as disturbances of embodied mechanisms (high-order domains based on the recycling of functionally germane sensorimotor circuits). We focus on two relevant lesion models: Parkinson's and Huntington's disease. First, we describe the physiopathology of both conditions as models of progressive frontostriatal impairment. Then, we summarize works assessing action language, motor-language coupling, and syntax in samples at early and preclinical disease stages. To conclude, we discuss the implications of the evidence for neurolinguistic modeling, identify key issues to be addressed in future research, and discuss potential clinical implications. In brief, our work seeks to open new theoretical and translational avenues for embodied cognition research.
Palabras clave: ACTION LANGUAGE , EMBODIED COGNITION , FRONTOSTRIATAL CIRCUITS , HUNTINGTON'S DISEASE , MOTOR-LANGUAGE COUPLING , PARKINSON'S DISEASE , SYNTAX
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/48771
DOI: https://dx.doi.org/10.1016/j.neubiorev.2017.07.011
URL: https://www.sciencedirect.com/science/article/pii/S0149763417300702
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Birba, Agustina; García, Adolfo Martín; Kozono, Giselle; Legaz, Agustina; Ibáñez Barassi, Agustín Mariano; et al.; Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson's and Huntington's disease; Pergamon-Elsevier Science Ltd; Neuroscience and Biobehavioral Reviews; 80; 9-2017; 673-687
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