Mostrar el registro sencillo del ítem
dc.contributor.author
Gonzalez Baro, Maria del Rosario
dc.contributor.author
Coleman, Rosalind A.
dc.date.available
2018-06-14T21:38:19Z
dc.date.issued
2017-01
dc.identifier.citation
Gonzalez Baro, Maria del Rosario; Coleman, Rosalind A.; Mitochondrial acyltransferases and glycerophospholipid metabolism; Elsevier Science; Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids; 1862; 1; 1-2017; 49-55
dc.identifier.issn
1388-1981
dc.identifier.uri
http://hdl.handle.net/11336/48732
dc.description.abstract
Our understanding of the synthesis and remodeling of mitochondrial phospholipids remains incomplete. Two isoforms of glycerol-3-phosphate acyltransferase (GPAT1 and 2) and two isoforms of acylglycerol-3-phosphate acyltransferase (AGPAT4 and 5) are located on the outer mitochondrial membrane, suggesting that both lysophosphatidic acid and phosphatidic acid are synthesized in situ for de novo glycerolipid biosynthesis. However, it is believed that the phosphatidic acid substrate for cardiolipin and phosphatidylethanolamine biosynthesis is produced at the endoplasmic reticulum whereas the phosphatidic acid synthesized in the mitochondria must be transferred to the endoplasmic reticulumbefore it undergoes additional steps to form the mature phospholipids that are trafficked back to the mitochondria. It is unclear whether mitochondrial phospholipids are remodeled by mitochondrial acyltransferases or whether lysophospholipids must return to the endoplasmic reticulum or to the mitochondrial associatedmembrane for reesterification. In this review we will focus on the few glycerolipid acyltransferases that are known to be mitochondrial. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Remodeling
dc.subject
Phosphatidic Acid
dc.subject
Mitochondrial Associated Membrane
dc.subject
Phospholipid
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Mitochondrial acyltransferases and glycerophospholipid metabolism
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-14T19:06:21Z
dc.journal.volume
1862
dc.journal.number
1
dc.journal.pagination
49-55
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Gonzalez Baro, Maria del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
dc.description.fil
Fil: Coleman, Rosalind A.. University of North Carolina; Estados Unidos
dc.journal.title
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbalip.2016.06.023
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1388198116301755
Archivos asociados