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dc.contributor.author
Curciarello, Renata  
dc.contributor.author
Docena, Guillermo H.  
dc.contributor.author
MacDonald, Thomas T.  
dc.date.available
2018-06-14T20:24:29Z  
dc.date.issued
2017-08  
dc.identifier.citation
Curciarello, Renata; Docena, Guillermo H.; MacDonald, Thomas T.; The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease; Frontiers Research Foundation; Frontiers in Medicine; 4; 8-2017  
dc.identifier.issn
2296-858X  
dc.identifier.uri
http://hdl.handle.net/11336/48715  
dc.description.abstract
Crohn?s disease is an idiopathic disorder of the gut thought to be caused by a combination<br />of environmental and genetic factors in susceptible individuals. It is characterized by<br />chronic transmural inflammation of the terminal ileum and colon, with typical transmural<br />lesions. Complications, including fibrosis, mean that between 40 and 70% of patients<br />require surgery in the first 10 years after diagnosis. Presently, there is no evidence that<br />the current therapies which dampen inflammation modulate or reverse intestinal fibrosis.<br />In this review, we focus on cytokines that may lead to fibrosis and stenosis and the<br />contribution of experimental models for understanding and treatment of gut fibrosis.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers Research Foundation  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
Crohn´S Disease  
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Fibrosis  
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Fibrostenosis  
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Cytokines  
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Strictures  
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Extracellular Matrix  
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Chronic Inflamation  
dc.subject.classification
Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-13T14:19:20Z  
dc.journal.volume
4  
dc.journal.pais
Suiza  
dc.journal.ciudad
Lausana  
dc.description.fil
Fil: Curciarello, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina. Queen Mary University of London; Reino Unido  
dc.description.fil
Fil: Docena, Guillermo H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina  
dc.description.fil
Fil: MacDonald, Thomas T.. Queen Mary University of London; Reino Unido  
dc.journal.title
Frontiers in Medicine  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmed.2017.00126/full  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fmed.2017.00126