Artículo
Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway
Beckwith, Esteban Javier
; Gorostiza, Ezequiel Axel
; Berni, Jimena
; Rezaval, Carolina
; Perez Santangelo, Agustin
; Nadra, Alejandro Daniel
; Ceriani, Maria Fernanda
Fecha de publicación:
10/12/2013
Editorial:
Public Library of Science
Revista:
PLoS Biology
ISSN:
1544-9173
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Living organisms use biological clocks to maintain their internal temporal order and anticipate daily environmental changes. In Drosophila, circadian regulation of locomotor behavior is controlled by ∼150 neurons; among them, neurons expressing the PIGMENT DISPERSING FACTOR (PDF) set the period of locomotor behavior under free-running conditions. To date, it remains unclear how individual circadian clusters integrate their activity to assemble a distinctive behavioral output. Here we show that the BONE MORPHOGENETIC PROTEIN (BMP) signaling pathway plays a crucial role in setting the circadian period in PDF neurons in the adult brain. Acute deregulation of BMP signaling causes period lengthening through regulation of dClock transcription, providing evidence for a novel function of this pathway in the adult brain. We propose that coherence in the circadian network arises from integration in PDF neurons of both the pace of the cell-autonomous molecular clock and information derived from circadian-relevant neurons through release of BMP ligands.
Palabras clave:
Pigment Dispersing Factor
,
Bone Morphogenetic Protein
,
Schnurri
,
Circadian
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Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Beckwith, Esteban Javier; Gorostiza, Ezequiel Axel; Berni, Jimena; Rezaval, Carolina; Perez Santangelo, Agustin; et al.; Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway; Public Library of Science; PLoS Biology; 11; 12; 10-12-2013; 1-15; e1001733
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