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dc.contributor.author
Hughes, Michael E.
dc.contributor.author
Abruzzi, Katherine C.
dc.contributor.author
Allada, Ravi
dc.contributor.author
Anafi, Ron
dc.contributor.author
Arpat, Alaaddin Bulak
dc.contributor.author
Asher, Gad
dc.contributor.author
Baldi, Pierre
dc.contributor.author
de Bekker, Charissa
dc.contributor.author
Bell Pedersen, Deborah
dc.contributor.author
Blau, Justin
dc.contributor.author
Brown, Steve
dc.contributor.author
Ceriani, Maria Fernanda
dc.contributor.author
Chen, Zheng
dc.contributor.author
Chiu, Joanna C.
dc.contributor.author
Cox, Juergen
dc.contributor.author
Crowell, Alexander M.
dc.contributor.author
DeBruyne, Jason P.
dc.contributor.author
Dijk, Derk-Jan
dc.contributor.author
DiTacchio, Luciano
dc.contributor.author
Doyle, Francis J.
dc.contributor.author
Duffield, Giles E.
dc.contributor.author
Dunlap, Jay C.
dc.contributor.author
Eckel Mahan, Kristin
dc.contributor.author
Esser, Karyn A.
dc.contributor.author
FitzGerald, Garret A.
dc.contributor.author
Forger, Daniel B.
dc.contributor.author
Francey, Lauren J.
dc.contributor.author
Fu, Ying Hui
dc.contributor.author
Gachon, Frédéric
dc.contributor.author
Gatfield, David
dc.contributor.author
de Goede, Paul
dc.contributor.author
Golden, Susan S.
dc.contributor.author
Green, Carla
dc.contributor.author
Harer, John
dc.contributor.author
Harmer, Stacey
dc.contributor.author
Haspel, Jeff
dc.contributor.author
Hastings, Michael H.
dc.contributor.author
Herzel, Hanspeter
dc.contributor.author
Herzog, Erik D.
dc.contributor.author
Hoffmann, Christy
dc.contributor.author
Hong, Christian
dc.contributor.author
Hughey, Jacob J.
dc.contributor.author
Hurley, Jennifer M.
dc.contributor.author
de la Iglesia, Daniel Horacio
dc.contributor.author
Johnson, Carl
dc.contributor.author
Kay, Steve A.
dc.contributor.author
Koike, Nobuya
dc.contributor.author
Kornacker, Karl
dc.contributor.author
Kramer, Achim
dc.contributor.author
Lamia, Katja
dc.contributor.author
Leise, Tanya
dc.contributor.author
Lewis, Scott A.
dc.contributor.author
Li, Jiajia
dc.contributor.author
Li, Xiaodong
dc.contributor.author
Liu, Andrew C.
dc.contributor.author
Loros, Jennifer J.
dc.contributor.author
Martino, Tami A.
dc.contributor.author
Menet, Jerome S.
dc.contributor.author
Merrow, Martha
dc.contributor.author
Millar, Andrew J.
dc.contributor.author
Mockler, Todd
dc.contributor.author
Naef, Felix
dc.contributor.author
Nagoshi, Emi
dc.contributor.author
Nitabach, Michael N.
dc.contributor.author
Olmedo, Maria
dc.contributor.author
Nusinow, Dmitri A.
dc.contributor.author
Ptácek, Louis J.
dc.contributor.author
Rand, David
dc.contributor.author
Reddy, Akhilesh B.
dc.contributor.author
Robles, Maria S.
dc.contributor.author
Roenneberg, Till
dc.contributor.author
Rosbash, Michael
dc.contributor.author
Ruben, Marc D.
dc.contributor.author
Rund, Samuel S.C.
dc.contributor.author
Sancar, Aziz
dc.contributor.author
Sassone Corsi, Paolo
dc.contributor.author
Sehgal, Amita
dc.contributor.author
Sherrill Mix, Scott
dc.contributor.author
Skene, Debra J.
dc.contributor.author
Storch, Kai Florian
dc.contributor.author
Takahashi, Joseph S.
dc.contributor.author
Ueda, Hiroki R.
dc.contributor.author
Wang, Han
dc.contributor.author
Weitz, Charles
dc.contributor.author
Westermark, P. O.
dc.contributor.author
Wijnen, Herman
dc.contributor.author
Xu, Ying
dc.contributor.author
Wu, Gang
dc.contributor.author
Yoo, Seung Hee
dc.contributor.author
Young, Michael
dc.contributor.author
Zhang, Eric Erquan
dc.contributor.author
Zielinski, Tomasz
dc.contributor.author
Hogenesch, John B.
dc.date.available
2018-06-14T17:54:18Z
dc.date.issued
2017-10
dc.identifier.citation
Hughes, Michael E.; Abruzzi, Katherine C.; Allada, Ravi; Anafi, Ron; Arpat, Alaaddin Bulak; et al.; Guidelines for Genome-Scale Analysis of Biological Rhythms; SAGE Publications; Journal of Biological Rhythms; 32; 5; 10-2017; 380-393
dc.identifier.issn
0748-7304
dc.identifier.uri
http://hdl.handle.net/11336/48680
dc.description.abstract
Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout the day. These methods hold significant promise for future discovery, particularly when combined with computational modeling. However, genome-scale experiments are costly and laborious, yielding “big data” that are conceptually and statistically difficult to analyze. There is no obvious consensus regarding design or analysis. Here we discuss the relevant technical considerations to generate reproducible, statistically sound, and broadly useful genome-scale data. Rather than suggest a set of rigid rules, we aim to codify principles by which investigators, reviewers, and readers of the primary literature can evaluate the suitability of different experimental designs for measuring different aspects of biological rhythms. We introduce CircaInSilico, a web-based application for generating synthetic genome biology data to benchmark statistical methods for studying biological rhythms. Finally, we discuss several unmet analytical needs, including applications to clinical medicine, and suggest productive avenues to address them.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SAGE Publications
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Biostatistics
dc.subject
Chip-Seq
dc.subject
Circadian Rhythms
dc.subject
Computational Biology
dc.subject
Diurnal Rhythms
dc.subject
Functional Genomics
dc.subject
Guidelines
dc.subject
Metabolomics
dc.subject
Proteomics
dc.subject
Rna-Seq
dc.subject
Systems Biology
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Guidelines for Genome-Scale Analysis of Biological Rhythms
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T15:11:25Z
dc.identifier.eissn
1552-4531
dc.journal.volume
32
dc.journal.number
5
dc.journal.pagination
380-393
dc.journal.pais
Estados Unidos
dc.journal.ciudad
California.
dc.description.fil
Fil: Hughes, Michael E.. Washington University School Of Medicine In St. Louis; Estados Unidos
dc.description.fil
Fil: Abruzzi, Katherine C.. Brandeis University; Estados Unidos
dc.description.fil
Fil: Allada, Ravi. Northwestern University; Estados Unidos
dc.description.fil
Fil: Anafi, Ron. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Arpat, Alaaddin Bulak. Universite de Lausanne; Suiza
dc.description.fil
Fil: Asher, Gad. Weizmann Institute Of Science Israel; Israel
dc.description.fil
Fil: Baldi, Pierre. University of California at Irvine; Estados Unidos
dc.description.fil
Fil: de Bekker, Charissa. University Of Central Florida; Estados Unidos
dc.description.fil
Fil: Bell Pedersen, Deborah. Texas A&M University; Estados Unidos
dc.description.fil
Fil: Blau, Justin. University of New York; Estados Unidos
dc.description.fil
Fil: Brown, Steve. Universitat Zurich; Suiza
dc.description.fil
Fil: Ceriani, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Chen, Zheng. University Of Texas Health Science Center At Houston; Estados Unidos
dc.description.fil
Fil: Chiu, Joanna C.. University of California at Davis; Estados Unidos
dc.description.fil
Fil: Cox, Juergen. Max Planck Institute Of Biochemistry; Alemania
dc.description.fil
Fil: Crowell, Alexander M.. Geisel School Of Medicine At Dartmouth; Estados Unidos
dc.description.fil
Fil: DeBruyne, Jason P.. Morehouse School Of Medicine; Estados Unidos
dc.description.fil
Fil: Dijk, Derk-Jan. University Of Surrey; Reino Unido
dc.description.fil
Fil: DiTacchio, Luciano. University Of Kansas Medical Center; Estados Unidos
dc.description.fil
Fil: Doyle, Francis J.. Harvard University; Estados Unidos
dc.description.fil
Fil: Duffield, Giles E.. University of Notre Dame; Estados Unidos
dc.description.fil
Fil: Dunlap, Jay C.. Geisel School Of Medicine At Dartmouth; Estados Unidos
dc.description.fil
Fil: Eckel Mahan, Kristin. University Of Texas Medical School At Houston; Estados Unidos
dc.description.fil
Fil: Esser, Karyn A.. University Of Florida College Of Medicine; Estados Unidos
dc.description.fil
Fil: FitzGerald, Garret A.. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Forger, Daniel B.. University Of Michigan; Estados Unidos
dc.description.fil
Fil: Francey, Lauren J.. Cincinnati Children's Hospital Medical Center; Estados Unidos
dc.description.fil
Fil: Fu, Ying Hui. University of California; Estados Unidos
dc.description.fil
Fil: Gachon, Frédéric. Nestlé Institute Of Health Sciences; Suiza
dc.description.fil
Fil: Gatfield, David. Universite de Lausanne; Suiza
dc.description.fil
Fil: de Goede, Paul. University Of Amsterdam; Países Bajos
dc.description.fil
Fil: Golden, Susan S.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Green, Carla. University of Texas; Estados Unidos
dc.description.fil
Fil: Harer, John. University of Duke; Estados Unidos
dc.description.fil
Fil: Harmer, Stacey. University of California at Davis; Estados Unidos
dc.description.fil
Fil: Haspel, Jeff. Washington University; Estados Unidos
dc.description.fil
Fil: Hastings, Michael H.. The Medical Research Council Laboratory Of Molecular Biology; Reino Unido
dc.description.fil
Fil: Herzel, Hanspeter. Charité Universitätsmedizin Berlin; Alemania
dc.description.fil
Fil: Herzog, Erik D.. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Hoffmann, Christy. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Hong, Christian. Cincinnati Children's Hospital Medical Center; Estados Unidos
dc.description.fil
Fil: Hughey, Jacob J.. Vanderbilt University School Of Medicine; Estados Unidos
dc.description.fil
Fil: Hurley, Jennifer M.. Rensselaer Polytechnic Institute; Estados Unidos
dc.description.fil
Fil: de la Iglesia, Daniel Horacio. University Of Washington; Estados Unidos
dc.description.fil
Fil: Johnson, Carl. Vanderbilt University; Estados Unidos
dc.description.fil
Fil: Kay, Steve A.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Koike, Nobuya. Kyoto Prefectural University Of Medicine; Japón
dc.description.fil
Fil: Kornacker, Karl. Ohio State University; Estados Unidos
dc.description.fil
Fil: Kramer, Achim. Charité Universitätsmedizin Berlin; Alemania
dc.description.fil
Fil: Lamia, Katja. The Scripps Research Institute; Estados Unidos
dc.description.fil
Fil: Leise, Tanya. Amherst College; Estados Unidos
dc.description.fil
Fil: Lewis, Scott A.. Washington University; Estados Unidos
dc.description.fil
Fil: Li, Jiajia. Washington University; Estados Unidos
dc.description.fil
Fil: Li, Xiaodong. Wuhan University; China
dc.description.fil
Fil: Liu, Andrew C.. The University Of Memphis; Estados Unidos
dc.description.fil
Fil: Loros, Jennifer J.. Geisel School Of Medicine At Dartmouth; Estados Unidos
dc.description.fil
Fil: Martino, Tami A.. University of Guelph; Canadá
dc.description.fil
Fil: Menet, Jerome S.. Texas A&M University; Estados Unidos
dc.description.fil
Fil: Merrow, Martha. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Millar, Andrew J.. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Mockler, Todd. Donald Danforth Plant Science Center; Estados Unidos
dc.description.fil
Fil: Naef, Felix. Ecole Polytechnique Federale de Lausanne; Suiza
dc.description.fil
Fil: Nagoshi, Emi. Universidad de Ginebra; Suiza
dc.description.fil
Fil: Nitabach, Michael N.. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Olmedo, Maria. Universidad de Sevilla; España
dc.description.fil
Fil: Nusinow, Dmitri A.. Donald Danforth Plant Science Center; Estados Unidos
dc.description.fil
Fil: Ptácek, Louis J.. University of California; Estados Unidos
dc.description.fil
Fil: Rand, David. University of Warwick; Reino Unido
dc.description.fil
Fil: Reddy, Akhilesh B.. The Francis Crick Institute; Reino Unido
dc.description.fil
Fil: Robles, Maria S.. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Roenneberg, Till. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Rosbash, Michael. Brandeis University; Estados Unidos
dc.description.fil
Fil: Ruben, Marc D.. Cincinnati Children's Hospital Medical Center; Estados Unidos
dc.description.fil
Fil: Rund, Samuel S.C.. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Sancar, Aziz. University of North Carolina; Estados Unidos
dc.description.fil
Fil: Sassone Corsi, Paolo. University of California at Irvine; Estados Unidos
dc.description.fil
Fil: Sehgal, Amita. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Sherrill Mix, Scott. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Skene, Debra J.. University Of Surrey; Reino Unido
dc.description.fil
Fil: Storch, Kai Florian. Mcgill University, Douglas Mental Health University Institute; Canadá
dc.description.fil
Fil: Takahashi, Joseph S.. Ut Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Ueda, Hiroki R.. The University of Tokyo; Japón
dc.description.fil
Fil: Wang, Han. Soochow University; China
dc.description.fil
Fil: Weitz, Charles. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Westermark, P. O.. Leibniz Institute For Farm Animal Biology; Alemania
dc.description.fil
Fil: Wijnen, Herman. University of Southampton; Reino Unido
dc.description.fil
Fil: Xu, Ying. Soochow University; China
dc.description.fil
Fil: Wu, Gang. Cincinnati Children's Hospital Medical Center; Estados Unidos
dc.description.fil
Fil: Yoo, Seung Hee. University of Texas; Estados Unidos
dc.description.fil
Fil: Young, Michael. The Rockefeller University; Estados Unidos
dc.description.fil
Fil: Zhang, Eric Erquan. National Institute Of Biological Sciences, Beijing; China
dc.description.fil
Fil: Zielinski, Tomasz. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Hogenesch, John B.. Cincinnati Children's Hospital Medical Center; Estados Unidos
dc.journal.title
Journal of Biological Rhythms
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0748730417728663
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0748730417728663
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