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dc.contributor.author Goszczynski, Daniel Estanislao
dc.contributor.author Papaleo Mazzucco, Juliana
dc.contributor.author Ripoli, María Verónica
dc.contributor.author Villarreal, Edgardo Leopoldo
dc.contributor.author Rogberg Muñoz, Andres
dc.contributor.author Mezzadra, Carlos Alberto
dc.contributor.author Melucci, Lilia Magdalena
dc.contributor.author Giovambattista, Guillermo
dc.date.available 2018-06-14T17:49:12Z
dc.date.issued 2016-03
dc.identifier.citation Goszczynski, Daniel Estanislao; Papaleo Mazzucco, Juliana; Ripoli, María Verónica; Villarreal, Edgardo Leopoldo; Rogberg Muñoz, Andres; et al.; Genetic characterisation of PPARG, CEBPA and RXRA, and their influence on meat quality traits in cattle; Korean Society of Animal Sciences and Technology; Journal of Animal Science and Technology; 58; 1; 3-2016; 1-9
dc.identifier.issn 2055-0391
dc.identifier.uri http://hdl.handle.net/11336/48668
dc.description.abstract Background: Peroxisome proliferator-activated receptor gamma (PPARG), CCAAT/enhancer binding protein alpha (CEBPA) and retinoid X receptor alpha (RXRA) are nuclear transcription factors that play important roles in regulation of adipogenesis and fat deposition. The objectives of this study were to characterise the variability of these three candidate genes in a mixed sample panel composed of several cattle breeds with different meat quality, validate single nucleotide polymorphisms (SNPs) in a local crossbred population (Angus - Hereford - Limousin) and evaluate their effects on meat quality traits (backfat thickness, intramuscular fat content and fatty acid composition), supporting the association tests with bioinformatic predictive studies. Results: Globally, nine SNPs were detected in the PPARG and CEBPA genes within our mixed panel, including a novel SNP in the latter. Three of these nine, along with seven other SNPs selected from the Single Nucleotide Polymorphism database (SNPdb), including SNPs in the RXRA gene, were validated in the crossbred population (N = 260). After validation, five of these SNPs were evaluated for genotype effects on fatty acid content and composition. Significant effects were observed on backfat thickness and different fatty acid contents (P < 0.05). Some of these SNPs caused slight differences in mRNA structure stability and/or putative binding sites for proteins. Conclusions: PPARG and CEBPA showed low to moderate variability in our sample panel. Variations in these genes, along with RXRA, may explain part of the genetic variation in fat content and composition. Our results may contribute to knowledge about genetic variation in meat quality traits in cattle and should be evaluated in larger independent populations.
dc.format application/pdf
dc.language.iso eng
dc.publisher Korean Society of Animal Sciences and Technology
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject POLYMORPHISM
dc.subject VARIATION
dc.subject ASSOCIATION
dc.subject COWS
dc.subject BEEF
dc.subject SNP
dc.subject.classification Otras Ciencias Veterinarias
dc.subject.classification Ciencias Veterinarias
dc.subject.classification CIENCIAS AGRÍCOLAS
dc.title Genetic characterisation of PPARG, CEBPA and RXRA, and their influence on meat quality traits in cattle
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-06-11T14:27:54Z
dc.journal.volume 58
dc.journal.number 1
dc.journal.pagination 1-9
dc.journal.pais Corea del Sur
dc.description.fil Fil: Goszczynski, Daniel Estanislao. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.description.fil Fil: Papaleo Mazzucco, Juliana. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
dc.description.fil Fil: Ripoli, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.description.fil Fil: Villarreal, Edgardo Leopoldo. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
dc.description.fil Fil: Rogberg Muñoz, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.description.fil Fil: Mezzadra, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
dc.description.fil Fil: Melucci, Lilia Magdalena. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
dc.description.fil Fil: Giovambattista, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.journal.title Journal of Animal Science and Technology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1186/s40781-016-0095-3
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://janimscitechnol.biomedcentral.com/articles/10.1186/s40781-016-0095-3
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)