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Artículo

Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices

Tasat, Deborah Ruth; Bruno, Marcos E.; Domingo, Mariela Gisele; Gurman, Pablo; Auciello, Orlando; Paparella, María Luisa; Evelson, Pablo AndrésIcon ; Guglielmotti, Maria BeatrizIcon ; Olmedo, Daniel GustavoIcon
Fecha de publicación: 11/2017
Editorial: Wiley-liss, Div John Wiley & Sons Inc
Revista: Journal of Biomedical Materials Research Part B-applied Biomaterials
ISSN: 1552-4973
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

Although Ultrananocrystalline diamond (UNCD) has been proposed as a coating material for titanium biomedical implants, the biological effects and toxicity of UNCD particles that could eventually detach have not been studied to date. The biokinetics and biological effects of UNCD compared to titanium dioxide (TiO2) nanoparticles was evaluated in vivo using Wistar rats (n = 30) i.p. injected with TiO2, UNCD or saline solution. After 6 months, blood, lung, liver, and kidney samples were histologically analyzed. Oxidative damage by membrane lipidperoxidation (thiobarbituric acid reactive substances-TBARS), generation of reactive oxygen species (superoxide anion- O2 -), and antioxidant enzymes (superoxide dismutase-SOD, catalase-CAT) was evaluated in lung and liver. Histologic observation showed agglomerates of TiO2 or UNCD in the parenchyma of the studied organs, though there were fewer UNCD than TiO2 deposits. In addition, TiO2 caused areas compatibles with foci of necrosis in the liver and renal hyaline cylinders. Regarding UNCD, no membrane damage (TBARS) or mobilization of enzymatic antioxidants was observed either in lung or liver samples. No variations in O2 - generation were observed in lung (Co: 35.1 ± 4.02 vs. UNCD: 48 ± 9.1, p > 0.05). Conversely, TiO2 exposure caused production of O2 - in alveolar macrophages and consumption of catalase (p < 0.05). The studied parameters suggest that UNCD caused neither biochemical nor histological alterations, and therefore may prove useful as a surface coating for biomedical implants.
Palabras clave: Biokinetics , Oxidative Metabolism , Titanium Dioxide , Ultrananocrystalline Diamond Nanoparticles
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/48643
DOI: https://dx.doi.org/10.1002/jbm.b.33777
URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.33777
Colecciones
Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Tasat, Deborah Ruth; Bruno, Marcos E.; Domingo, Mariela Gisele; Gurman, Pablo; Auciello, Orlando; et al.; Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part B-applied Biomaterials; 105; 8; 11-2017; 2408-2415
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