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dc.contributor.author
Solimo, Aldana  
dc.contributor.author
Soraires Santacruz, Maria Cristina  
dc.contributor.author
Loaiza Perez, Andrea Irene  
dc.contributor.author
Bal, Elisa Dora  
dc.contributor.author
Finkielsztein, Liliana Mónica  
dc.contributor.author
Callero, Mariana Alejandra  
dc.date.available
2018-06-14T14:49:37Z  
dc.date.issued
2018-06  
dc.identifier.citation
Solimo, Aldana; Soraires Santacruz, Maria Cristina; Loaiza Perez, Andrea Irene; Bal, Elisa Dora; Finkielsztein, Liliana Mónica; et al.; N4-aryl substituted thiosemicarbazones derived from 1-indanones as potential anti-tumor agents for breast cancer treatment; Wiley-liss, Div John Wiley & Sons Inc; Journal of Cellular Physiology; 233; 6; 6-2018; 4677-4687  
dc.identifier.issn
0021-9541  
dc.identifier.uri
http://hdl.handle.net/11336/48632  
dc.description.abstract
Breast cancer is the first cause of cancer death in women. Many patients are resistant to current therapies, and even those were sensitive at first may eventually become resistant later. Thiosemicarbazones (TSCs) are synthetic compounds that exhibit several pharmacological activities. In this study, we investigated the potential anti-tumor activity of a set of N4-arylsubstituted TSCs (N4-TSCs) on human breast cancer cell lines. Studies on the effect of N4-TSCs (T1, T2, and T3) were carried on MCF-7, MDA-MB 231, and BT 474 cell lines which differ in their expression of ER, PR, and Her2/neu. Non-transformed MCF-10A breast cell line were used as normal cells. Action of N4-TSCs were evaluated by proliferation assay, quantification of apoptosis and cell cycle analysis. Modulation of clonogenic efficiency and migratory capacity by N4-TSCs were also evaluated. We further investigated the effects of N4-TSCs on ROS level and Ribonucleotide Reductase (RR) activity. We analyzed the action of these compounds on cellular mammosphere-forming capacity. We found that T1 and T2 had specific anti-tumor effect on all breast cancer cell lines based on their pro-apoptotic action and inhibitory effect on clonogenic efficiency and cell migration capacity. We also showed that both compounds increased ROS level and inhibited RR activity. Finally, we found that all N4-TSCs diminished mammospehere-forming capacity of MCF-7 and BT 474 cells. N4-TSCs showed specific anti-tumor action on human breast cancer cells independently their biomarkers expression pattern. Our results place these compounds as promising novel anti-tumor drugs with potential therapeutic application against different types of breast cancer.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Human Breast Cancer  
dc.subject
N4-Tscs  
dc.subject
Ribonucleotide Reductase  
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Ros  
dc.subject.classification
Bioquímica y Biología Molecular  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
N4-aryl substituted thiosemicarbazones derived from 1-indanones as potential anti-tumor agents for breast cancer treatment  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-13T15:08:48Z  
dc.journal.volume
233  
dc.journal.number
6  
dc.journal.pagination
4677-4687  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Solimo, Aldana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Soraires Santacruz, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina  
dc.description.fil
Fil: Loaiza Perez, Andrea Irene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Finkielsztein, Liliana Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina  
dc.description.fil
Fil: Callero, Mariana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.journal.title
Journal of Cellular Physiology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/jcp.26240  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.26240