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dc.contributor.author
Hilton, Hugo G.
dc.contributor.author
McMurtrey, Curtis P.
dc.contributor.author
Han, Alex S.
dc.contributor.author
Djaoud, Zakia
dc.contributor.author
Guethlein, Lisbeth A.
dc.contributor.author
Blokhuis, Jeroen H.
dc.contributor.author
Pugh, Jason L.
dc.contributor.author
Goyos, Ana
dc.contributor.author
Horowitz, Amir
dc.contributor.author
Buchli, Rico
dc.contributor.author
Jackson, Ken W.
dc.contributor.author
Bardet, Wilfred
dc.contributor.author
Bushnell, David A.
dc.contributor.author
Robinson, Philip J.
dc.contributor.author
Mendoza, Juan L
dc.contributor.author
Birnbaum, Michael E.
dc.contributor.author
Nielsen, Morten
dc.contributor.author
Garcia, K. Christopher
dc.contributor.author
Hildebrand, William H.
dc.contributor.author
Parham, Peter
dc.date.available
2018-06-14T14:00:40Z
dc.date.issued
2017-05
dc.identifier.citation
Hilton, Hugo G.; McMurtrey, Curtis P.; Han, Alex S.; Djaoud, Zakia; Guethlein, Lisbeth A.; et al.; The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands; Elsevier Science; Cell Reports; 19; 7; 5-2017; 1394-1405
dc.identifier.issn
2211-1247
dc.identifier.uri
http://hdl.handle.net/11336/48614
dc.description.abstract
HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B∗46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B∗46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B∗46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The HLA-B∗46:01 peptidome is predicted to be enriched for peptide antigens derived from Mycobacterium leprae. Overall, the results indicate that the distinctive peptidome and functions of HLA-B∗46:01 provide carriers with resistance to leprosy, which drove its rapid rise in frequency in Southeast Asia.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Antigen Presentation
dc.subject
Genetic Polymorphism
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Hla Class I
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Host-Pathogen Interactions
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Kir
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Mass Spectrometry
dc.subject
Modern Human Migration
dc.subject
Peptidome
dc.subject.classification
Salud Ocupacional
dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T14:58:06Z
dc.journal.volume
19
dc.journal.number
7
dc.journal.pagination
1394-1405
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Hilton, Hugo G.. University of Stanford; Estados Unidos
dc.description.fil
Fil: McMurtrey, Curtis P.. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Han, Alex S.. University of Stanford; Estados Unidos
dc.description.fil
Fil: Djaoud, Zakia. University of Stanford; Estados Unidos
dc.description.fil
Fil: Guethlein, Lisbeth A.. University of Stanford; Estados Unidos
dc.description.fil
Fil: Blokhuis, Jeroen H.. University of Stanford; Estados Unidos
dc.description.fil
Fil: Pugh, Jason L.. University of Stanford; Estados Unidos
dc.description.fil
Fil: Goyos, Ana. University of Stanford; Estados Unidos
dc.description.fil
Fil: Horowitz, Amir. University of Stanford; Estados Unidos
dc.description.fil
Fil: Buchli, Rico. Pure Protein LLC; Estados Unidos
dc.description.fil
Fil: Jackson, Ken W.. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Bardet, Wilfred. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Bushnell, David A.. University of Stanford; Estados Unidos
dc.description.fil
Fil: Robinson, Philip J.. University of Stanford; Estados Unidos
dc.description.fil
Fil: Mendoza, Juan L. University of Stanford; Estados Unidos
dc.description.fil
Fil: Birnbaum, Michael E.. University of Stanford; Estados Unidos
dc.description.fil
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.description.fil
Fil: Garcia, K. Christopher. University of Stanford; Estados Unidos
dc.description.fil
Fil: Hildebrand, William H.. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Parham, Peter. University of Stanford; Estados Unidos
dc.journal.title
Cell Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.celrep.2017.04.059
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124717305703
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