Mostrar el registro sencillo del ítem
dc.contributor.author
Pedersen, Lasse E.
dc.contributor.author
Patch, Jared R.
dc.contributor.author
Kenney, Mary
dc.contributor.author
Glabman, Raisa A.
dc.contributor.author
Nielsen, Morten
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Jungersen, Gregers
dc.contributor.author
Buus, Soren
dc.contributor.author
Golde, William T.
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2018-06-14T14:00:27Z
dc.date.issued
2016-11
dc.identifier.citation
Pedersen, Lasse E.; Patch, Jared R.; Kenney, Mary; Glabman, Raisa A.; Nielsen, Morten; et al.; Expanding specificity of class I restricted CD8+ T cells for viral epitopes following multiple inoculations of swine with a human adenovirus vectored foot-and-mouth disease virus (FMDV) vaccine; Elsevier Science; Veterinary Immunology And Immunopathology; 181; 11-2016; 59-67
dc.identifier.issn
0165-2427
dc.identifier.uri
http://hdl.handle.net/11336/48612
dc.description.abstract
The immune response to the highly acute foot-and-mouth disease virus (FMDV) is routinely reported as a measure of serum antibody. However, a critical effector function of immune responses combating viral infection of mammals is the cytotoxic T lymphocyte (CTL) response mediated by virus specific CD8 expressing T cells. This immune mechanism arrests viral spread by killing virus infected cells before new, mature virus can develop. We have previously shown that infection of swine by FMDV results in a measurable CTL response and have correlated CTL killing of virus-infected cells with specific class I major histocompatibility complex (MHC) tetramer staining. We also showed that a modified replication defective human adenovirus 5 vector expressing the FMDV structural proteins (Ad5-FMDV-T vaccine) targets the induction of a CD8+ CTL response with a minimal humoral response. In this report, we show that the specificity of the CD8+ T cell response to Ad5-FMDV-T varies between cohorts of genetically identical animals. Further, we demonstrate epitope specificity of CD8+ T cells expands following multiple immunizations with this vaccine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Class I
dc.subject
Cytotoxic T Lymphocytes
dc.subject
Mhc
dc.subject
Mhc Tetramers
dc.subject
Sla
dc.subject
T Cell Epitopes
dc.subject.classification
Salud Ocupacional
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias de la Salud
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Expanding specificity of class I restricted CD8+ T cells for viral epitopes following multiple inoculations of swine with a human adenovirus vectored foot-and-mouth disease virus (FMDV) vaccine
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T14:57:51Z
dc.journal.volume
181
dc.journal.pagination
59-67
dc.journal.pais
Países Bajos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Pedersen, Lasse E.. United States Department of Agriculture. Agricultural Research Service; Argentina. Technical University of Denmark; Dinamarca
dc.description.fil
Fil: Patch, Jared R.. United States Department of Agriculture. Agricultural Research Service; Argentina. University of Vermont; Estados Unidos
dc.description.fil
Fil: Kenney, Mary. United States Department of Agriculture. Agricultural Research Service; Argentina
dc.description.fil
Fil: Glabman, Raisa A.. United States Department of Agriculture. Agricultural Research Service; Argentina. University of Vermont; Estados Unidos
dc.description.fil
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.description.fil
Fil: Jungersen, Gregers. Technical University of Denmark; Dinamarca
dc.description.fil
Fil: Buus, Soren. Universidad de Copenhagen; Dinamarca
dc.description.fil
Fil: Golde, William T.. United States Department of Agriculture. Agricultural Research Service; Argentina
dc.journal.title
Veterinary Immunology And Immunopathology
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.vetimm.2016.07.012
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165242716301404
Archivos asociados