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dc.contributor.author
Palumbo, María Laura  
dc.contributor.author
Di Rosso, María Emilia  
dc.contributor.author
Simon, Elias Hugo  
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Gonzalez Murano, Maria Rosa  
dc.contributor.author
Genaro, Ana Maria  
dc.date.available
2018-06-13T21:15:01Z  
dc.date.issued
2018-07  
dc.identifier.citation
Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, Maria Rosa; Genaro, Ana Maria; Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 107; 7-2018; 26-34  
dc.identifier.issn
1043-4666  
dc.identifier.uri
http://hdl.handle.net/11336/48589  
dc.description.abstract
It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Academic Press Ltd - Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Chronic Stress  
dc.subject
Cytokines  
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Hippocampus  
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Lymph Nodes  
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Glatiramer Acetate  
dc.subject.classification
Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-13T15:08:21Z  
dc.journal.volume
107  
dc.journal.pagination
26-34  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Philadelphia  
dc.description.fil
Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina  
dc.description.fil
Fil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; Argentina  
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Fil: Simon, Elias Hugo. Universidad de Buenos Aires. Facultad de Medicina; Argentina  
dc.description.fil
Fil: Gonzalez Murano, Maria Rosa. Pontificia Universidad Católica Argentina ; Argentina  
dc.description.fil
Fil: Genaro, Ana Maria. Pontificia Universidad Católica Argentina ; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina  
dc.journal.title
Cytokine  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.cyto.2017.11.010  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043466617303526