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dc.contributor.author
Palma, Sabina
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dc.contributor.author
Zwenger, Ariel
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dc.contributor.author
Croce, María Virginia
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dc.contributor.author
Abba, Martín Carlos
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dc.contributor.author
Lacunza, Ezequiel
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dc.date.available
2018-06-13T21:14:49Z
dc.date.issued
2016-06
dc.identifier.citation
Palma, Sabina; Zwenger, Ariel; Croce, María Virginia; Abba, Martín Carlos; Lacunza, Ezequiel; From Molecular Biology to Clinical Trials: Toward Personalized Colorectal Cancer Therapy; Cig Media Group; Clinical Colorectal Cancer; 15; 2; 6-2016; 104-115
dc.identifier.issn
1533-0028
dc.identifier.uri
http://hdl.handle.net/11336/48587
dc.description.abstract
During the past years, molecular studies through high-throughput technologies have led to the confirmation of critical alterations in colorectal cancer (CRC) and the discovery of some new ones, including mutations, DNA methylations, and structural chromosomal changes. These genomic alterations might act in concert to dysregulate specific signaling pathways that normally exert their functions on critical cell phenotypes, including the regulation of cellular metabolism, proliferation, differentiation, and survival. Targeted therapy against key components of altered signaling pathways has allowed an improvement in CRC treatment. However, a significant percentage of patients with CRC and metastatic CRC will not benefit from these targeted therapies and will be restricted to systemic chemotherapy. Mechanisms of resistance have been associated with specific gene alterations. To fully understand the nature and significance of the genetic and epigenetic defects in CRC that might favor a tumor evading a given therapy, much work remains. Therefore, a dynamic link between basic molecular research and preclinical studies, which ultimately constitute the prelude to standardized therapies, is very important to provide better and more effective treatments against CRC. We present an updated revision of the main molecular features of CRC and their associated therapies currently under study in clinical trials. Moreover, we performed an unsupervised classification of CRC clinical trials with the aim of obtaining an overview of the future perspectives of preclinical studies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cig Media Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Clinical Trials
dc.subject
Colorectal Cancer
dc.subject
Genomic Alterations
dc.subject
Signaling Pathways
dc.subject
Targeted Therapy
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
From Molecular Biology to Clinical Trials: Toward Personalized Colorectal Cancer Therapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T14:19:27Z
dc.journal.volume
15
dc.journal.number
2
dc.journal.pagination
104-115
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Dallas
dc.description.fil
Fil: Palma, Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Zwenger, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia del Neuquen. Hospital Provincial Neuquen "dr. E. Castro Rendon"; Argentina
dc.description.fil
Fil: Croce, María Virginia. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Lacunza, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.journal.title
Clinical Colorectal Cancer
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.clcc.2015.11.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1533002815001462
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