Artículo
Biological activities of Zn(II)- S -methyl-cysteine complex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects
Escudero, Graciela; Martini, Nancy
; Jori, Khalil
; Jori, Nadir; Maresca, Nahuel Rafael; Laino, Carlos Horacio; Naso, Luciana Gissella
; Williams, Patricia Ana María; Ferrer, Evelina Gloria
Fecha de publicación:
03/2016
Editorial:
Taylor & Francis
Revista:
Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN:
1475-6366
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The antidepressant effect of simple Zn(II) salts has been proved in several animal models of depression. In this study, a coordination metal complex of Zn(II) having a sulfur containing ligand is tested as antidepressant for the first time. Forced swimming test method on male Wistar rats shows a decrease in the immobility and an increase in the swimming behavior after treatment with [Zn(S-Met)2] (S-Met=S-methyl-l-cysteine) being more effective and remarkable than ZnCl2. The thiobarbituric acid and the pyranine consumption (hydroxyl and peroxyl radicals, respectively) methods were applied to evaluate the antioxidant activity of S-Met and [Zn(S-Met)2] showing evidence of attenuation of hydroxyl but not peroxyl radicals activities. UV-vis studies on the inhibition of acid phosphatase enzyme (AcP) demonstrated that S-methyl-l-cysteine did not produce any effect but, in contrast, [Zn(S-Met)2] complex behaved as a moderate inhibitor. Finally, bioavailability studies were performed by fluorescence spectroscopy denoting the ability of the albumin to transport the complex.
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Articulos(CEQUINOR)
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Citación
Escudero, Graciela; Martini, Nancy; Jori, Khalil; Jori, Nadir; Maresca, Nahuel Rafael; et al.; Biological activities of Zn(II)- S -methyl-cysteine complex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects; Taylor & Francis; Journal of Enzyme Inhibition and Medicinal Chemistry; 31; 6; 3-2016; 1625-1631
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