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dc.contributor.author
Islas, María Soledad
dc.contributor.author
Luengo, Alicia
dc.contributor.author
Franca, Carlos Alberto
dc.contributor.author
Merino, Mercedes Griera
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Calleros, Laura
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Rodriguez Puyol, Manuel
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Lezama, Luis
dc.contributor.author
Ferrer, Evelina Gloria
dc.contributor.author
Williams, Patricia Ana María
dc.date.available
2018-06-13T18:37:05Z
dc.date.issued
2016-10
dc.identifier.citation
Islas, María Soledad; Luengo, Alicia; Franca, Carlos Alberto; Merino, Mercedes Griera; Calleros, Laura; et al.; Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes; Springer; Journal of Biological Inorganic Chemistry; 21; 7; 10-2016; 851-863
dc.identifier.issn
0949-8257
dc.identifier.uri
http://hdl.handle.net/11336/48572
dc.description.abstract
The coordination compound of the antihypertensive ligand irbesartan (irb) with copper(II) (CuIrb) was synthesized and characterized by FTIR, FT-Raman, UV–visible, reflectance and EPR spectroscopies. Experimental evidence allowed the implementation of structural and vibrational studies by theoretical calculations made in the light of the density functional theory (DFT). This compound was designed to induce structural modifications on the ligand. No antioxidant effects were displayed by both compounds, though CuIrb behaved as a weak 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·) scavenger (IC50 = 425 μM). The measurements of the contractile capacity on human mesangial cell lines showed that CuIrb improved the antihypertensive effects of the parent medication. In vitro cell growth inhibition against prostate cancer cell lines (LNCaP and DU 145) was measured for CuIrb, irbesartan and copper(II). These cell lines have been selected since the angiotensin II type 1 (AT1) receptor (that was blocked by the angiotensin receptor blockers, ARB) has been identified in them. The complex exerted anticancer behavior (at 100 μM) improving the activity of the ligand. Flow cytometry determinations were used to determine late apoptotic mechanisms of cell death.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Irbesartan
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Antioxidant
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Antihypertensive
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Cytotoxicity
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-12T13:32:49Z
dc.identifier.eissn
1432-1327
dc.journal.volume
21
dc.journal.number
7
dc.journal.pagination
851-863
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Islas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
dc.description.fil
Fil: Luengo, Alicia. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.description.fil
Fil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
dc.description.fil
Fil: Merino, Mercedes Griera. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.description.fil
Fil: Calleros, Laura. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.description.fil
Fil: Rodriguez Puyol, Manuel. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.description.fil
Fil: Lezama, Luis. Universidad del País Vasco; España
dc.description.fil
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
dc.description.fil
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
dc.journal.title
Journal of Biological Inorganic Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00775-016-1384-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00775-016-1384-5


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