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dc.contributor.author
Islas, María Soledad  
dc.contributor.author
Luengo, Alicia  
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Franca, Carlos Alberto  
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Merino, Mercedes Griera  
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Calleros, Laura  
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Rodriguez Puyol, Manuel  
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Lezama, Luis Raul  
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Ferrer, Evelina Gloria  
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Williams, Patricia Ana María  
dc.date.available
2018-06-13T18:37:05Z  
dc.date.issued
2016-10  
dc.identifier.citation
Islas, María Soledad; Luengo, Alicia; Franca, Carlos Alberto; Merino, Mercedes Griera; Calleros, Laura; et al.; Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes; Springer; Journal of Biological Inorganic Chemistry; 21; 7; 10-2016; 851-863  
dc.identifier.issn
0949-8257  
dc.identifier.uri
http://hdl.handle.net/11336/48572  
dc.description.abstract
The coordination compound of the antihypertensive ligand irbesartan (irb) with copper(II) (CuIrb) was synthesized and characterized by FTIR, FT-Raman, UV–visible, reflectance and EPR spectroscopies. Experimental evidence allowed the implementation of structural and vibrational studies by theoretical calculations made in the light of the density functional theory (DFT). This compound was designed to induce structural modifications on the ligand. No antioxidant effects were displayed by both compounds, though CuIrb behaved as a weak 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·) scavenger (IC50 = 425 μM). The measurements of the contractile capacity on human mesangial cell lines showed that CuIrb improved the antihypertensive effects of the parent medication. In vitro cell growth inhibition against prostate cancer cell lines (LNCaP and DU 145) was measured for CuIrb, irbesartan and copper(II). These cell lines have been selected since the angiotensin II type 1 (AT1) receptor (that was blocked by the angiotensin receptor blockers, ARB) has been identified in them. The complex exerted anticancer behavior (at 100 μM) improving the activity of the ligand. Flow cytometry determinations were used to determine late apoptotic mechanisms of cell death.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ANTIHYPERTENSIVE  
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ANTIOXIDANT  
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COPPER(II) COMPLEX  
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CYTOTOXICITY  
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IRBESARTAN  
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Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
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info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-12T13:32:49Z  
dc.identifier.eissn
1432-1327  
dc.journal.volume
21  
dc.journal.number
7  
dc.journal.pagination
851-863  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlin  
dc.description.fil
Fil: Islas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina  
dc.description.fil
Fil: Luengo, Alicia. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España  
dc.description.fil
Fil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina  
dc.description.fil
Fil: Merino, Mercedes Griera. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España  
dc.description.fil
Fil: Calleros, Laura. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España  
dc.description.fil
Fil: Rodriguez Puyol, Manuel. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España  
dc.description.fil
Fil: Lezama, Luis Raul. Universidad del País Vasco; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
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Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina  
dc.description.fil
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina  
dc.journal.title
Journal of Biological Inorganic Chemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00775-016-1384-5  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00775-016-1384-5