Mostrar el registro sencillo del ítem

dc.contributor.author
Catalano Dupuy, Daniela Luján
dc.contributor.author
Lopez Rivero, Arleth Susana
dc.contributor.author
Soldano, Anabel
dc.contributor.author
Ceccarelli, Eduardo Augusto
dc.date.available
2016-03-17T18:21:29Z
dc.date.issued
2013-01
dc.identifier.citation
Catalano Dupuy, Daniela Luján; Lopez Rivero, Arleth Susana; Soldano, Anabel; Ceccarelli, Eduardo Augusto; Redox Proteins as Targets for Drugs Development against Pathogens; Bentham Science Publishers; Current Pharmaceutical Design.; 19; 14; 1-2013; 2594-2605
dc.identifier.issn
1381-6128
dc.identifier.uri
http://hdl.handle.net/11336/4845
dc.description.abstract
Antimicrobial drug resistance in pathogens is an increasing human health problem. The rapid loss of effectiveness in antibiotics treatments and the accumulation of multi-resistant microbial strains are increasing worldwide threats. Moreover, several infectious diseases have been neglected for years and new antimicrobial treatments are lacking. In other cases, complexity of infectious organisms has exceeded the efforts to find new drugs to control them. Thus, strategies for the proper development of specific drugs are critically needed. Redox metabolism has already been proved to be a useful target for drug development. During the last years a significant number of electron carriers, enzymes, proteins and protein complexes have been studied and some of them were found to be essential for survival of several microbial pathogens. This review will focus on three major redox metabolic pathways which may provide promising strategies to fight against pathogens: the non-mevalonate pathway for isoprenoids biosynthesis, the iron metabolism and the iron-sulfur proteins. The common attractive link of all these processes is the plant-type ferredoxin-NADP+ reductase, an enzyme that participates in numerous electron transfer reactions and has no homologous enzyme in humans. Research in these redox pathways will open new perspectives for the rational design of drugs against infectious diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Reacciones Redox
dc.subject
Antibióticos
dc.subject
Ferredoxina-Nadp+ Reductasa
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Redox Proteins as Targets for Drugs Development against Pathogens
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
19
dc.journal.number
14
dc.journal.pagination
2594-2605
dc.journal.pais
Emiratos Árabes Unidos
dc.journal.ciudad
Sharjah
dc.description.fil
Fil: Catalano Dupuy, Daniela Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Lopez Rivero, Arleth Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Soldano, Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Ceccarelli, Eduardo Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.journal.title
Current Pharmaceutical Design.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/108198/article
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.2174/1381612811319140009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1381612811319140009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/23116397


Archivos asociados

Documento no disponible

Comunidades y colecciones

  • Articulos(IBR) [352]
    Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO

Mostrar el registro sencillo del ítem