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dc.contributor.author
Naso, Luciana Gissella  
dc.contributor.author
Badiola, Iker  
dc.contributor.author
Marquez Clavijo, Joana  
dc.contributor.author
Valcarcel, María  
dc.contributor.author
Salado, Clarisa  
dc.contributor.author
Ferrer, Evelina Gloria  
dc.contributor.author
Williams, Patricia Ana María  
dc.date.available
2018-06-12T20:09:35Z  
dc.date.issued
2016-11  
dc.identifier.citation
Naso, Luciana Gissella; Badiola, Iker; Marquez Clavijo, Joana; Valcarcel, María; Salado, Clarisa; et al.; Inhibition of the metastatic progression of breast and colorectal cancer in vitro and in vivo in murine model by the oxidovanadium(IV) complex with luteolin; Pergamon-Elsevier Science Ltd; Bioorganic & Medicinal Chemistry; 24; 22; 11-2016; 6004-6011  
dc.identifier.issn
0968-0896  
dc.identifier.uri
http://hdl.handle.net/11336/48423  
dc.description.abstract
The anticancer and antimetastatic behavior of the flavonoid luteolin and its oxidovanadium(IV) complex [VO(lut)(H2O)2]Na.3H2O (VOlut) has been investigated. Considering that the complex displayed strong anticancer activity on MDAMB231 human breast cancer cell line we herein determined through in vitro assays that the complex would probably reduce breast cancer cell metastasis in a higher extent than the natural antioxidant. In the CT26 colon cancer cell line a stronger anticancer effect has also been determined for the complex (IC50 0.9 μM) and in addition it did not exert toxic effects on normal colon epithelial cells at concentrations up to 10 µM. Working with a murine model of highly aggressive, orthotopic colon cancer model (CT26 cancer cell lines) it has been determined that the complex might prevent metastatic dissemination of the colon cancer cells to the liver. The flavonoid luteolin also exerted anticancer effects (at a low degree, IC50 5.9 μM) on CT26 cell line and produced a 24% reduction of colon cancer liver metastasis.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Oxidovanadium(Iv) Complex  
dc.subject
Luteolin  
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Antitumor  
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Antimetastasic  
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Murine Cancer Model  
dc.subject.classification
Otras Ciencias Químicas  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Inhibition of the metastatic progression of breast and colorectal cancer in vitro and in vivo in murine model by the oxidovanadium(IV) complex with luteolin  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-12T13:33:09Z  
dc.journal.volume
24  
dc.journal.number
22  
dc.journal.pagination
6004-6011  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina  
dc.description.fil
Fil: Badiola, Iker. Universidad del País Vasco; España  
dc.description.fil
Fil: Marquez Clavijo, Joana. Universidad del País Vasco; España  
dc.description.fil
Fil: Valcarcel, María. Parque científico y Tecnológico de Bizkaia; España  
dc.description.fil
Fil: Salado, Clarisa. Parque científico y Tecnológico de Bizkaia; España  
dc.description.fil
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina  
dc.description.fil
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina  
dc.journal.title
Bioorganic & Medicinal Chemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.bmc.2016.09.058  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0968089616308070