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dc.contributor.author
Pajoro, Alice
dc.contributor.author
Madrigal, Pedro
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Muiño, Jose M.
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Matus, José Tomás
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Jin, Jian
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Mecchia, Martin Alejandro
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dc.contributor.author
Debernardi, Juan Manuel
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Palatnik, Javier Fernando
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Balazadeh, Salma
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Arif, Muhammad
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Ó’Maoiléidigh, Diarmuid S.
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Wellmer, Frank
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Krajewsk, Pawel
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Riechmann, José Luis
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Angenent, Gerco C.
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Kaufmann, Kerstin
dc.date.available
2016-03-17T18:07:11Z
dc.date.issued
2014-03
dc.identifier.citation
Pajoro, Alice; Madrigal, Pedro; Muiño, Jose M.; Matus, José Tomás; Jin, Jian; et al.; Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development; Biomed Central; Genome Biology; 15; 3; 3-2014; 1-18
dc.identifier.issn
1474-760X
dc.identifier.uri
http://hdl.handle.net/11336/4835
dc.description.abstract
Background: Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master regulators of developmental switches and organ specification. However, the mechanisms by which these factors dynamically regulate the expression of their target genes at different developmental stages are still poorly understood. Results: We characterized the relationship of chromatin accessibility, gene expression, and DNA binding of two MADS-domain proteins at different stages of Arabidopsis flower development. Dynamic changes in APETALA1 and SEPALLATA3 DNA binding correlated with changes in gene expression, and many of the target genes could be associated with the developmental stage in which they are transcriptionally controlled. We also observe dynamic changes in chromatin accessibility during flower development. Remarkably, DNA binding of APETALA1 and SEPALLATA3 is largely independent of the accessibility status of their binding regions and it can precede increases in DNA accessibility. These results suggest that APETALA1 and SEPALLATA3 may modulate chromatin accessibility, thereby facilitating access of other transcriptional regulators to their target genes. Conclusions: Our findings indicate that different homeotic factors regulate partly overlapping, yet also distinctive sets of target genes in a partly stage-specific fashion. By combining the information from DNA-binding and gene expression data, we are able to propose models of stage-specific regulatory interactions, thereby addressing dynamics of regulatory networks throughout flower development. Furthermore, MADS-domain TFs may regulate gene expression by alternative strategies, one of which is modulation of chromatin accessibility
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Biomed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Mads Box
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Chromatin Remodelling
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Mir396
dc.subject
Grf
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
15
dc.journal.number
3
dc.journal.pagination
1-18
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Pajoro, Alice. Wageningen University. Laboratory of Molecular Biology; Países Bajos
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Fil: Madrigal, Pedro. Polish Academy of Sciences. Institute of Plant Genetics; Polonia
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Fil: Muiño, Jose M.. Max-Planck Institute for Molecular Genetics. Department of Computational Molecular Biology; Alemania
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Fil: Matus, José Tomás. Universidad de Barcelona. Center for Research in Agricultural Genomics; España
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Fil: Jin, Jian. Universidad de Barcelona. Center for Research in Agricultural Genomics; España
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Fil: Mecchia, Martin Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
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Fil: Debernardi, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
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Fil: Palatnik, Javier Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Balazadeh, Salma. University of Potsdam. Institute of Biochemistry and Biology; Alemania
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Fil: Arif, Muhammad. University of Potsdam. Institute of Biochemistry and Biology; Alemania
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Fil: Ó’Maoiléidigh, Diarmuid S.. Trinity College Dublin. Smurfit Institute of Genetics; Irlanda
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Fil: Wellmer, Frank. Trinity College Dublin. Smurfit Institute of Genetics; Irlanda
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Fil: Krajewsk, Pawel. Polish Academy of Sciences. Institute of Plant Genetics; Polonia
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Fil: Riechmann, José Luis . Universidad de Barcelona. Center for Research in Agricultural Genomics; España. Institució Catalana de Recerca i Estudis Avançats; España
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Fil: Angenent, Gerco C.. Wageningen University. Laboratory of Molecular Biology; Países Bajos. Plant Research International. Business Unit Bioscience; Países Bajos
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Fil: Kaufmann, Kerstin. Wageningen University. Laboratory of Molecular Biology; Países Bajos. University of Potsdam. Institute of Biochemistry and Biology; Alemania
dc.journal.title
Genome Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://genomebiology.biomedcentral.com/articles/10.1186/gb-2014-15-3-r41
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info:eu-repo/semantics/altIdentifier/pmid/PMC4054849
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info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054849/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1186/gb-2014-15-3-r41
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186%2Fgb-2014-15-3-r41
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