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dc.contributor.author
Girardini Brovelli, Javier Enrique
dc.contributor.author
Marotta, Carolina
dc.contributor.author
del Sal, Giannino
dc.date.available
2016-03-16T20:32:06Z
dc.date.issued
2013-11
dc.identifier.citation
Girardini Brovelli, Javier Enrique; Marotta, Carolina; del Sal, Giannino; Disarming mutant p53 oncogenic function; Elsevier; Pharmacological Research; 79; 11-2013; 75-87
dc.identifier.issn
1043-6618
dc.identifier.uri
http://hdl.handle.net/11336/4827
dc.description.abstract
In the last decade intensive research has confirmed the long standing hypothesis that some p53 point mutants acquire novel activities able to cooperate with oncogenic mechanisms. Particular attention has attracted the ability of several such mutants to actively promote the development of aggressive and metastatic tumors in vivo. This knowledge opens a new dimension on rational therapy design, suggesting novel strategies based on pharmacological manipulation of those neomorphic activities. P53 point mutants have several characteristics that make them attractive targets for anti-cancer therapies. Remarkably, mutant p53 has been found predominantly in tumor cells and may act pleiotropically by interfering with a variety of cellular processes. Therefore, drugs targeting mutant p53 may selectively affect tumor cells, inactivating simultaneously several mechanisms of tumor promotion. Moreover, the high frequency of missense mutations on the p53 gene suggests that interfering with mutant p53 function may provide a valuable approach for the development of efficient therapies able to target a wide range of tumor types.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Mutant P53
dc.subject
Cancer
dc.subject
Metastasis
dc.subject.classification
Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Disarming mutant p53 oncogenic function
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
79
dc.journal.pagination
75-87
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Girardini Brovelli, Javier Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Marotta, Carolina. Laboratorio Nazionale CIB; Italia. Università degli Studi di Trieste. Dipartimento di Scienze della Vita; Italia
dc.description.fil
Fil: del Sal, Giannino. Laboratorio Nazionale CIB; Italia. Università degli Studi di Trieste. Dipartimento di Scienze della Vita; Italia
dc.journal.title
Pharmacological Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1043661813001783
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phrs.2013.11.003
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phrs.2013.11.003
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/24246451
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