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Artículo

Antioxidant, anticancer activities and mechanistic studies of the flavone glycoside diosmin and its oxidovanadium(IV) complex. Interactions with bovine serum albumin

Naso, Luciana GissellaIcon ; Martinez, Valeria RominaIcon ; Lezama, Luis; Salado, Clarisa; Valcarcel, María; Ferrer, Evelina GloriaIcon ; Williams, Patricia Ana María
Fecha de publicación: 09/2016
Editorial: Pergamon-Elsevier Science Ltd
Revista: Bioorganic & Medicinal Chemistry
ISSN: 0968-0896
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Químicas

Resumen

The natural antioxidant flavonoid diosmin, found in citric fruits, showed low antioxidant properties among other flavonoids due to its structural characteristics and low cytotoxicity against lung (A549) and breast (T47D, SKBR3 and MDAMB231) cancer cell lines. The anticancer behavior has been improved by the metal complex generated with the flavonoid and the oxidovanadium(IV) ion. This new complex, [VO(dios)(OH)3]Na5·6H2O (VOdios), has been synthesized and characterized both in solid and solution states. The interaction of the metal ion through the sugar moiety of diosmin precluded the improvement of the antioxidant effects. However, the cell-killing effects tested in human lung A549 and breast T47D, SKBR3 and MDAMB231 cancer cell lines, were enhanced by complexation. The anti-proliferative effects on the human lung cancer cell line were accompanied by cellular ROS generation and an increase in cytoplasm condensation. The breast cancer cell lines did not produce caspase3/7 activation, mitochondrial potential reduction and ROS generation. Therefore, a non-apoptotic form of cell death in a caspase- and oxidative stress-independent manner has been proposed. The protein binding ability has been monitored by the quenching of tryptophan emission in the presence of the compounds using bovine serum albumin (BSA) as a model protein. Both compounds could be distributed and transported in vivo and the complex displayed stronger binding affinity and higher contributions to the hydrogen bond and van der Waals forces.
Palabras clave: Diosmin , Oxidovanadium(Iv) Complexes , Antioxidant , Anticancer , Bsa Binding
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/48258
DOI: https://dx.doi.org/10.1016/j.bmc.2016.06.053
URL: https://www.sciencedirect.com/science/article/pii/S096808961630476X
Colecciones
Articulos(CEQUINOR)
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Citación
Naso, Luciana Gissella; Martinez, Valeria Romina; Lezama, Luis; Salado, Clarisa; Valcarcel, María; et al.; Antioxidant, anticancer activities and mechanistic studies of the flavone glycoside diosmin and its oxidovanadium(IV) complex. Interactions with bovine serum albumin; Pergamon-Elsevier Science Ltd; Bioorganic & Medicinal Chemistry; 24; 18; 9-2016; 4108-4119
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