Mostrar el registro sencillo del ítem
dc.contributor.author
Naso, Luciana Gissella
dc.contributor.author
Lezama, Luis
dc.contributor.author
Valcarcel, María
dc.contributor.author
Salado, Clarisa
dc.contributor.author
Villacé, Patricia
dc.contributor.author
Kortazar, Danel
dc.contributor.author
Ferrer, Evelina Gloria
dc.contributor.author
Williams, Patricia Ana María
dc.date.available
2018-06-12T14:17:19Z
dc.date.issued
2016-04
dc.identifier.citation
Naso, Luciana Gissella; Lezama, Luis; Valcarcel, María; Salado, Clarisa; Villacé, Patricia; et al.; Bovine serum albumin binding, antioxidant and anticancer properties of an oxidovanadium(IV) complex with luteolin; Elsevier Science Inc; Journal of Inorganic Biochemistry; 157; 4-2016; 80-93
dc.identifier.issn
0162-0134
dc.identifier.uri
http://hdl.handle.net/11336/48257
dc.description.abstract
Chemotherapy using metal coordination compounds for cancer treatment is the work of the ongoing research.Continuing our research on the improvement of the anticancer activity of natural flavonoids by metal complexation,a coordination compound of the natural antioxidant flavone luteolin (lut) and the oxidovanadium(IV) cationhas been synthesized and characterized. Using different physicochemical measurements some structural aspects of [VO(lut)(H2O)2]Na·3H2O (VOlut) were determined. The metal coordinated to two cis-deprotonated oxygen atoms (ArO−) of the ligand and two H2O molecules. Magnetic measurements in solid state indicatedthe presence of an effective exchange pathway between adjacent vanadiumions. VOlut improved the antioxidant capacity of luteolin only against hydroxyl radical. The antitumoral effects were evaluated on MDAMB231 breastcancer and A549 lung cancer cell lines. VOlut exhibited higher viability inhibition (IC50=17 μM) than the ligand on MDAMB231 cells but they have the same behavior on A549 cells (ca. IC50=60 μM). At least oxidative stressprocesses were active during cancer cell-killing. When metals chelated through the carbonyl group and one adjacent OH group of the flavonoid an effective improvement of the biological properties has been observed. In VOlut the different coordination may be the cause of the small improvement of some of the tested properties of the flavonoid. Luteolin and VOlut could be distributed and transported in vivo. Luteolin interacted in the microenvironment of the tryptophan group of the serum binding protein, BSA, by means of electrostatic forces and its complex bind the protein by H bonding and van derWaals interactions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Luteolin
dc.subject
Oxidovanadium(Iv) Complexes
dc.subject
Magnetic Properties
dc.subject
Mechanisms of Cytotoxic Action
dc.subject
Bsa Binding
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Bovine serum albumin binding, antioxidant and anticancer properties of an oxidovanadium(IV) complex with luteolin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-12T13:31:11Z
dc.journal.volume
157
dc.journal.pagination
80-93
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.description.fil
Fil: Lezama, Luis. Universidad del País Vasco; España. Parque científico y Tecnológico de Bizkaia; España
dc.description.fil
Fil: Valcarcel, María. Parque científico y Tecnológico de Bizkaia; España
dc.description.fil
Fil: Salado, Clarisa. Parque científico y Tecnológico de Bizkaia; España
dc.description.fil
Fil: Villacé, Patricia. Parque científico y Tecnológico de Bizkaia; España
dc.description.fil
Fil: Kortazar, Danel. Parque científico y Tecnológico de Bizkaia; España
dc.description.fil
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.description.fil
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.journal.title
Journal of Inorganic Biochemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.jinorgbio.2016.01.021
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013416300216
Archivos asociados