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dc.contributor.author
Guisoni, Nara Cristina
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dc.contributor.author
Martinez Corral, Rosa
dc.contributor.author
Garcia Ojalvo, Jordi
dc.contributor.author
de Navascués, Joaquín
dc.date.available
2018-06-11T20:58:37Z
dc.date.issued
2017-04
dc.identifier.citation
Guisoni, Nara Cristina; Martinez Corral, Rosa; Garcia Ojalvo, Jordi; de Navascués, Joaquín; Diversity of fate outcomes in cell pairs under lateral inhibition; Company of Biologists; Development; 144; 7; 4-2017; 1177-1186
dc.identifier.issn
0950-1991
dc.identifier.uri
http://hdl.handle.net/11336/48191
dc.description.abstract
Cell fate determination by lateral inhibition via Notch/Delta signalling has been extensively studied. Most formalised models consider Notch/Delta interactions in fields of cells, with parameters that typically lead to symmetry breaking of signalling states between neighbouring cells, commonly resulting in salt-and-pepper fate patterns. Here, we consider the case of signalling between isolated cell pairs, and find that the bifurcation properties of a standard mathematical model of lateral inhibition can lead to stable symmetric signalling states. We apply this model to the adult intestinal stem cell (ISC) of Drosophila, the fate of which is stochastic but dependent on the Notch/Delta pathway. We observe a correlation between signalling state in cell pairs and their contact area. We interpret this behaviour in terms of the properties of our model in the presence of population variability in contact areas, which affects the effective signalling threshold of individual cells. Our results suggest that the dynamics of Notch/Delta signalling can contribute to explain stochasticity in stem cell fate decisions, and that the standard model for lateral inhibition can account for a wider range of developmental outcomes than previously considered.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Company of Biologists
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Intestinal Stem Cells
dc.subject
Lateral Inhibition
dc.subject
Neutral Competition
dc.subject
Notch-Delta Signalling
dc.subject
Symmetric Cell Division
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Diversity of fate outcomes in cell pairs under lateral inhibition
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-08T14:25:48Z
dc.journal.volume
144
dc.journal.number
7
dc.journal.pagination
1177-1186
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Guisoni, Nara Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Martinez Corral, Rosa. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Garcia Ojalvo, Jordi. Universitat Pompeu Fabra; España
dc.description.fil
Fil: de Navascués, Joaquín. Cardiff University; Reino Unido
dc.journal.title
Development
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1242/dev.137950
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/144/7/1177
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