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dc.contributor.author
Felice, Betiana
dc.contributor.author
Prabhakaran, Molamma P.
dc.contributor.author
Zamani, Maedeh
dc.contributor.author
Rodriguez, Andrea Paola
dc.contributor.author
Ramakrishna, Seeram
dc.date.available
2018-06-11T20:43:46Z
dc.date.issued
2015-12
dc.identifier.citation
Felice, Betiana; Prabhakaran, Molamma P.; Zamani, Maedeh; Rodriguez, Andrea Paola; Ramakrishna, Seeram; Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile; John Wiley & Sons Ltd; Polymer International; 64; 12; 12-2015; 1722-1732
dc.identifier.issn
0959-8103
dc.identifier.uri
http://hdl.handle.net/11336/48182
dc.description.abstract
Encapsulation of bioactive molecules within polymeric particles is a challenge, due to several limitations including low drug-loading efficiency, unwanted release profile, polydispersity and batch to batch variation in reproducibility, along with the limitations to scale up the process. It is essential to control the morphology of pure polymer particles in the first instance, in order to obtain the desired release profile of the drugs from the particles during the later stage. Here, we present the preparation of electrosprayed particles from water soluble FDA-approved polymer, namely polyvinyl alcohol (PVA) as an approach towards short-term drug delivery vehicle. Through electrospraying and varying the solvent ratios, three different sizes of particles were prepared, with sizes ranging from 500 to 2000 nm. Insulin was chosen as a model bioactive molecule, and the release profile of the drug was studied after incorporation in PVA particles. Fractional release plots obtained showed short-term release of insulin, within the first 60 minutes. Release curves were analyzed according to Ritger-Peppas model, suggesting Fickian diffusion as the predominant insulin release mechanism from PVA particles. This work suggests electrosprayed PVA particles as an innovative drug delivery system for short-term administration of drugs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Electrospraying
dc.subject
Electrospinning
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Drug Delivery
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Particles
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Pva
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Insulin
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Recubrimientos y Películas
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-04T21:43:49Z
dc.journal.volume
64
dc.journal.number
12
dc.journal.pagination
1722-1732
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Felice, Betiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina
dc.description.fil
Fil: Prabhakaran, Molamma P.. National University of Singapore; Singapur
dc.description.fil
Fil: Zamani, Maedeh. National University of Singapore; Singapur
dc.description.fil
Fil: Rodriguez, Andrea Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina
dc.description.fil
Fil: Ramakrishna, Seeram. National University of Singapore; Singapur
dc.journal.title
Polymer International
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/pi.4972
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/pi.4972


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