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dc.contributor.author
Ceriani, Maria Fernanda
dc.contributor.author
Hogenesch, John B.
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Yanovsky, Marcelo Javier
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Panda, Satchidananda
dc.contributor.author
Straume, Martin
dc.contributor.author
Kay, Steve A.
dc.date.available
2018-06-11T19:29:31Z
dc.date.issued
2002-11
dc.identifier.citation
Ceriani, Maria Fernanda; Hogenesch, John B.; Yanovsky, Marcelo Javier; Panda, Satchidananda; Straume, Martin; et al.; Genome-Wide Expression Analysis in Drosophila Reveals Genes Controlling Circadian Behavior; Society for Neuroscience; Journal of Neuroscience; 22; 21; 11-2002; 9305-9319
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/48143
dc.description.abstract
In Drosophila, a number of key processes such as emergence from the pupal case, locomotor activity, feeding, olfaction, and aspects of mating behavior are under circadian regulation. Although we have a basic understanding of how the molecular oscillations take place, a clear link between gene regulation and downstream biological processes is still missing. To identify clock-controlled output genes, we have used an oligonucleotide-based high-density array that interrogates gene expression changes on a whole genome level. We found genes regulating various physiological processes to be under circadian transcriptional regulation, ranging from protein stability and degradation, signal transduction, heme metabolism, detoxification, and immunity. By comparing rhythmically expressed genes in the fly head and body, we found that the clock has adapted its output functions to the needs of each particular tissue, implying that tissue-specific regulation is superimposed on clock control of gene expression. Finally, taking full advantage of the fly as a model system, we have identified and characterized a cycling potassium channel protein as a key step in linking the transcriptional feedback loop to rhythmic locomotor behavior.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Genechip Affymetrix
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Drosophila
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Slowpoke
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Arrthythmic Behavior
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Genome-Wide Expression Analysis in Drosophila Reveals Genes Controlling Circadian Behavior
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-10T15:46:45Z
dc.identifier.eissn
1529-2401
dc.journal.volume
22
dc.journal.number
21
dc.journal.pagination
9305-9319
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Ceriani, Maria Fernanda. The Scripps Research Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Hogenesch, John B.. Genomics Institute of the Novartis Research Foundation; Estados Unidos
dc.description.fil
Fil: Yanovsky, Marcelo Javier. The Scripps Research Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Panda, Satchidananda. Genomics Institute of the Novartis Research Foundation; Estados Unidos. The Scripps Research Institute; Estados Unidos
dc.description.fil
Fil: Straume, Martin. University Of Virginia; Estados Unidos
dc.description.fil
Fil: Kay, Steve A.. Genomics Institute of the Novartis Research Foundation; Estados Unidos. The Scripps Research Institute; Estados Unidos
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/22/21/9305.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/JNEUROSCI.22-21-09305.2002
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