Artículo

Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains

Negrotto, SoledadIcon ; Mena, Hebe AgustinaIcon ; Ure, Agustin EnriqueIcon ; Jaquenod de Giusti, CarolinaIcon ; Bollati Fogolín, Mariela; Vermeulen, Elba MonicaIcon ; Schattner, Mirta AnaIcon ; Gomez, Ricardo MartinIcon
Fecha de publicación: 07/2015
Editorial: American Society for Microbiology
Revista: Journal of Virology
ISSN: 0022-538X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The Junín virus (JUNV) arenavirus is the etiologic agent of Argentina Haemorrhagic Fever (AHF). We characterised the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection by the C#1 strain (attenuated), and even more, by the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expressions after infection with both JUNV strains.
Palabras clave: Argentine Haemorrhagic Fever , Arenavirus , Dendritic Cells , Human
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/48115
DOI: https://dx.doi.org/10.1128/JVI.01014-15
URL: http://jvi.asm.org/content/89/14/7409
Colecciones
Articulos(IBBM)
Articulos de INST.DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Citación
Negrotto, Soledad; Mena, Hebe Agustina; Ure, Agustin Enrique; Jaquenod de Giusti, Carolina; Bollati Fogolín, Mariela; et al.; Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains; American Society for Microbiology; Journal of Virology; 89; 14; 7-2015; 7409-7413
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