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dc.contributor.author
García, Adolfo Martín
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Bocanegra, Yamile
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Herrera, Eduar
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Pino, Mariana
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Muñoz , Edinson
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Sedeño, Lucas
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Ibañez, Agustin Mariano
dc.date.available
2018-06-08T20:55:39Z
dc.date.issued
2017-02
dc.identifier.citation
García, Adolfo Martín; Bocanegra, Yamile; Herrera, Eduar; Pino, Mariana; Muñoz , Edinson; et al.; Action-semantic and syntactic deficits in subjects at risk for Huntington's disease; British Psychological Soc; Journal Of Neuropsychology; 2-2017; 1-20
dc.identifier.issn
1748-6645
dc.identifier.uri
http://hdl.handle.net/11336/48013
dc.description.abstract
Frontostriatal networks play critical roles in grounding action semantics and syntactic skills. Indeed, their atrophy distinctively disrupts both domains, as observed in patients with Huntington's disease (HD) and Parkinson's disease, even during early disease stages. However, frontostriatal degeneration in these conditions may begin up to 15 years before the onset of clinical symptoms, opening avenues for pre‐clinical detection via sensitive tasks. Such a mission is particularly critical in HD, given that patients’ children have 50% chances of inheriting the disease. Against this background, we assessed whether deficits in the above‐mentioned domains emerge in subjects at risk to develop HD. We administered tasks tapping action semantics, object semantics, and two forms of syntactic processing to 18 patients with HD, 19 asymptomatic first‐degree relatives, and sociodemographically matched controls for each group. The patients evinced significant deficits in all tasks, but only those in the two target domains were independent of overall cognitive state. More crucially, relative to controls, the asymptomatic relatives were selectively impaired in action semantics and in the more complex syntactic task, with both patterns emerging irrespective of the subjects’ overall cognitive state. Our findings highlight the relevance of these dysfunctions as potential prodromal biomarkers of HD. Moreover, they offer theoretical insights into the differential contributions of frontostriatal hubs to both domains while paving the way for innovations in diagnostic procedures.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
British Psychological Soc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Huntington'S Disease
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Asymptomatic First-Degree Relatives
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Action Semantics
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Syntax
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Preclinical Detection
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Action-semantic and syntactic deficits in subjects at risk for Huntington's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-07T14:09:53Z
dc.journal.pagination
1-20
dc.journal.pais
Reino Unido
dc.description.fil
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt.; Argentina
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Fil: Bocanegra, Yamile. Universidad de Antioquia; Colombia
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Fil: Herrera, Eduar. Universidad de Cali; Colombia
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Fil: Pino, Mariana. Universidad Autónoma del Caribe; Colombia
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Fil: Muñoz , Edinson. Universidad de Santiago de Chile; Chile
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Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt.; Argentina
dc.description.fil
Fil: Ibáñez Barassi, Agustín Mariano. Universidad Autónoma del Caribe; Colombia. Universidad de Santiago de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt.; Argentina
dc.journal.title
Journal Of Neuropsychology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jnp.12120
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jnp.12120
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