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dc.contributor.author
Currie, Joshua D.
dc.contributor.author
Kawaguchi, Akane
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Traspas, Ricardo Moreno
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Schuez, Maritta
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Chara, Osvaldo
dc.contributor.author
Tanaka, Elly M.
dc.date.available
2018-06-08T20:37:00Z
dc.date.issued
2016-11
dc.identifier.citation
Currie, Joshua D.; Kawaguchi, Akane; Traspas, Ricardo Moreno; Schuez, Maritta; Chara, Osvaldo; et al.; Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal Choreography of Diverse Connective Tissue Progenitor Pools; Cell Press; Developmental Cell; 39; 4; 11-2016; 411-423
dc.identifier.issn
1534-5807
dc.identifier.uri
http://hdl.handle.net/11336/47998
dc.description.abstract
Connective tissues—skeleton, dermis, pericytes, fascia—are a key cell source for regenerating the patterned skeleton during axolotl appendage regeneration. This complexity has made it difficult to identify the cells that regenerate skeletal tissue. Inability to identify these cells has impeded a mechanistic understanding of blastema formation. By tracing cells during digit tip regeneration using brainbow transgenic axolotls, we show that cells from each connective tissue compartment have distinct spatial and temporal profiles of proliferation, migration, and differentiation. Chondrocytes proliferate but do not migrate into the regenerate. In contrast, pericytes proliferate, then migrate into the blastema and give rise solely to pericytes. Periskeletal cells and fibroblasts contribute the bulk of digit blastema cells and acquire diverse fates according to successive waves of migration that choreograph their proximal-distal and tissue contributions. We further show that platelet-derived growth factor signaling is a potent inducer of fibroblast migration, which is required to form the blastema.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Axolotl
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Blastema Formation
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Brainbow
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Cell Migration
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Connective Tissue
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Limb Regeneration
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Live Imaging
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Pdgf Signaling
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Skeletal Regeneration
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal Choreography of Diverse Connective Tissue Progenitor Pools
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-08T14:25:52Z
dc.journal.volume
39
dc.journal.number
4
dc.journal.pagination
411-423
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Currie, Joshua D.. Technische Universität Dresden; Alemania. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
dc.description.fil
Fil: Kawaguchi, Akane. Technische Universität Dresden; Alemania
dc.description.fil
Fil: Traspas, Ricardo Moreno. Technische Universität Dresden; Alemania
dc.description.fil
Fil: Schuez, Maritta. Technische Universität Dresden; Alemania
dc.description.fil
Fil: Chara, Osvaldo. Technische Universität Dresden; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
dc.description.fil
Fil: Tanaka, Elly M.. Technische Universität Dresden; Alemania. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
dc.journal.title
Developmental Cell
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.devcel.2016.10.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1534580716307511
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