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dc.contributor.author
Han, Yong
dc.contributor.author
Faudone, Sonia Nerina
dc.contributor.author
Zitto, Gustavo
dc.contributor.author
Bonafede, Silvina
dc.contributor.author
Rosasco, María Ana
dc.contributor.author
Segall, Adriana Ines
dc.date.available
2018-06-08T19:58:21Z
dc.date.issued
2017-01
dc.identifier.citation
Han, Yong; Faudone, Sonia Nerina; Zitto, Gustavo; Bonafede, Silvina; Rosasco, María Ana; et al.; Physicochemical Characterization of Physical Mixture and Solid Dispersion of Diclofenac Potassium with Mannitol; JAPSonlines; Journal of Applied Pharmaceutical Science; 7; 1; 1-2017; 204-208
dc.identifier.issn
2231-3354
dc.identifier.uri
http://hdl.handle.net/11336/47961
dc.description.abstract
Diclofenac potassium is an anti-inflammatory agent classified as a class II drug as per the biopharmaceutical classification system (BCS). The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. There are several techniques to enhance the dissolution of poorly soluble drugs. Methods available include salt formation, micronization and addition of solvent or surface active agents. The objective of the present work is to improve the dissolution profile of diclofenac potassium by formation of a physical mixture and a solid dispersion with mannitol. The solid dispersion was prepared by solvent method using ethanol/water. As diclofenac potassium melts with decomposition, the compatibility study with mannitol was done with the acid form by differential scanning calorimetry (DSC). The dissolution properties and physicochemical properties of diclofenac potassium:mannitol physical mixture and solid dispersion were investigated by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and dissolution test. This study shows that the dissolution rate of diclofenac potassium can be enhanced considerably by formulating it with mannitol, as a physical mixture or as a solid dispersion although crystallinity was maintained.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
JAPSonlines
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Solid Dispersio
dc.subject
Diclofenac Potassium
dc.subject
Mannitol
dc.subject.classification
Salud Ocupacional
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Physicochemical Characterization of Physical Mixture and Solid Dispersion of Diclofenac Potassium with Mannitol
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-06T19:40:13Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
204-208
dc.journal.pais
India
dc.description.fil
Fil: Han, Yong. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina
dc.description.fil
Fil: Faudone, Sonia Nerina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina
dc.description.fil
Fil: Zitto, Gustavo. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina
dc.description.fil
Fil: Bonafede, Silvina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina
dc.description.fil
Fil: Rosasco, María Ana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina
dc.description.fil
Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Journal of Applied Pharmaceutical Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.7324/JAPS.2017.70130
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.japsonline.com/abstract.php?article_id=2140


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