Artículo
Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
Kerber, R.; Reindl, S.; Romanowski, Victor
; Gomez, Ricardo Martin
; Ogbaini Emovon, E.; Günther, S.; ter Meulen, J.
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
03/2015
Editorial:
Elsevier Science
Revista:
Journal of Clinical Virology
ISSN:
1386-6532
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Significant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research.
Palabras clave:
Arenavirus
,
Viral Hemorrhagic Fever
,
Lassa Virus
,
Junin Virus
,
Vaccine
,
Antiviral
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Articulos(IBBM)
Articulos de INST.DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Articulos de INST.DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Citación
Kerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; et al.; Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps; Elsevier Science; Journal of Clinical Virology; 64; 3-2015; 120-127
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