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Artículo

Potential Impact of Changes in the Schedule for Primary Diphtheria-Tetanus Toxoids-Pertussis Immunization as Control Strategy for Pertussis

Bergero, Paula ElenaIcon ; Fabricius, GabrielIcon ; Hozbor, Daniela FlaviaIcon ; Theeten, Heidi; Hens, Niel
Fecha de publicación: 02/2018
Editorial: Lippincott Williams
Revista: Pediatric Infectious Disease Journal
ISSN: 0891-3668
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Background: Pertussis is a vaccine-preventable respiratory disease that may cause death mainly in infants. The schedules for primary pertussis vaccination are set in each country by the local health authorities. Several different schedules meet World Health Organization recommendations, 2–4–6 months, 6–10–14 weeks, 2–3–4 months and 3–4–5 months being the most commonly used worldwide. In this work, we analyze the benefits of changing the vaccination schedule to control the disease. Methods: We used an age-structured deterministic mathematical model for pertussis transmission to compute the incidences for the 4 above-mentioned schedules. Different vaccination coverages and vaccine effectiveness levels were considered. Immunization data from Argentina and Belgium were used. Results: The highest reduction in incidence was obtained by adopting the 6–10–14 weeks schedule, reaching about a 36% reduction of 0–1-year incidence with respect to the 2–4–6 months schedule. We show the dependence of this reduction on both vaccine effectiveness and coverage. The severe pertussis incidence decreased significantly when the first dose of the 2–4–6 months schedule was accelerated to 6 weeks. Finally, we estimated that the communication campaign adopted in Flanders (Belgium) to improve compliance with the vaccine schedule could lead to a reduction of 16% in severe pertussis incidence and about 7% in total incidence in infants. Conclusions: Our work highlights the use of mathematical modeling to quantify the benefits of the existing vaccination schedules and the strategies that could be implemented to improve their compliance. Our results indicated that the 6–10–14 weeks is the best schedule option and that the Belgium vaccination campaign significantly reduced the incidence of severe cases.
Palabras clave: Pertussis , Schedules , Mathematical Model , Epidemiology
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/47928
DOI: https://dx.doi.org/10.1097/INF.0000000000001752
URL: https://insights.ovid.com/crossref?an=00006454-201802000-00018
Colecciones
Articulos(IBBM)
Articulos de INST.DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Articulos(INIFTA)
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Citación
Bergero, Paula Elena; Fabricius, Gabriel; Hozbor, Daniela Flavia; Theeten, Heidi; Hens, Niel; Potential Impact of Changes in the Schedule for Primary Diphtheria-Tetanus Toxoids-Pertussis Immunization as Control Strategy for Pertussis; Lippincott Williams; Pediatric Infectious Disease Journal; 37; 2; 2-2018; e36-e42
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