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dc.contributor.author
Smith, Keith
dc.contributor.author
Ricaud, Benjamin
dc.contributor.author
Shahid, Nauman
dc.contributor.author
Rhodes, Stephen
dc.contributor.author
Starr, John M.
dc.contributor.author
Ibañez, Agustin Mariano
dc.contributor.author
Parra, Mario A.
dc.contributor.author
Escudero, Javier
dc.contributor.author
Vandergheynst, Pierre
dc.date.available
2018-06-08T17:11:18Z
dc.date.issued
2017-02
dc.identifier.citation
Smith, Keith; Ricaud, Benjamin; Shahid, Nauman; Rhodes, Stephen; Starr, John M.; et al.; Locating Temporal Functional Dynamics of Visual Short-Term Memory Binding using Graph Modular Dirichlet Energy; Nature Publishing Group; Scientific Reports; 7; 2-2017; 1-12
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/47883
dc.description.abstract
Visual short-term memory binding tasks are a promising early marker for Alzheimer´s disease (AD). To uncover functional deficits of AD in these tasks it is meaningful to first study unimpaired brain function. Electroencephalogram recordings were obtained from encoding and maintenance periods of tasks performed by healthy young volunteers. We probe the task´s transient physiological underpinnings by contrasting shape only (Shape) and shape-colour binding (Bind) conditions, displayed in the left and right sides of the screen, separately. Particularly, we introduce and implement a novel technique named Modular Dirichlet Energy (MDE) which allows robust and flexible analysis of the functional network with unprecedented temporal precision. We find that connectivity in the Bind condition is less integrated with the global network than in the Shape condition in occipital and frontal modules during the encoding period of the right screen condition. Using MDE we are able to discern driving effects in the occipital module between 100-140 ms, coinciding with the P100 visually evoked potential, followed by a driving effect in the frontal module between 140-180 ms, suggesting that the differences found constitute an information processing difference between these modules. This provides temporally precise information over a heterogeneous population in promising tasks for the detection of AD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Binding
dc.subject
Dementia
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Diagnostic Markers
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Working Memory
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Locating Temporal Functional Dynamics of Visual Short-Term Memory Binding using Graph Modular Dirichlet Energy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-07T14:07:56Z
dc.journal.volume
7
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Smith, Keith. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Ricaud, Benjamin. École Polytechnique Fédérale de Lausanne; Suiza
dc.description.fil
Fil: Shahid, Nauman. École Polytechnique Fédérale de Lausanne; Suiza
dc.description.fil
Fil: Rhodes, Stephen. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Starr, John M.. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Autόnoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. ARC Centre of Excellence in Cognition and its Disorder; Australia
dc.description.fil
Fil: Parra, Mario A.. University of Edinburgh; Reino Unido. Universidad Autόnoma del Caribe; Colombia. Heriot-Watt University; Reino Unido
dc.description.fil
Fil: Escudero, Javier. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Vandergheynst, Pierre. École Polytechnique Fédérale de Lausanne; Suiza
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1038/srep42013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep42013
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