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dc.contributor.author
Abrevaya, Sofia  
dc.contributor.author
Sedeño, Lucas  
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Fittipaldi, María Sol  
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Pineda, David  
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Lopera, Francisco  
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Buritica, Omar  
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Villegas, Andrés  
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Bustamante, Catalina  
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Gomez, Diana  
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Trujillo, Natalia  
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Pautassi, Ricardo Marcos  
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Ibañez, Agustin Mariano  
dc.contributor.author
García, Adolfo Martín  
dc.date.available
2018-06-08T17:11:11Z  
dc.date.issued
2016-12  
dc.identifier.citation
Abrevaya, Sofia; Sedeño, Lucas; Fittipaldi, María Sol; Pineda, David; Lopera, Francisco; et al.; The Road Less Traveled: Alternative Pathways for Action-Verb Processing in Parkinson’s Disease; IOS Press; Journal of Alzheimer's Disease; 55; 4; 12-2016; 1429-1435  
dc.identifier.issn
1387-2877  
dc.identifier.uri
http://hdl.handle.net/11336/47882  
dc.description.abstract
Action verbs are critically embodied in motor brain networks. In Parkinson´s disease (PD), damage to the latter compromises access to such words. However, patients are not fully incapable of processing them, as their performance is far from floor level. Here we tested the hypothesis that action-verb processing in PD may rely on alternative disembodied semantic circuits. Seventeen PD patients and 15 healthy controls listened to action verbs and nouns during functional MRI scanning. Using cluster-mass analysis with a permutation test, we assessed task-related functional connectivity considering seeds differentially engaged by action and non-action words (namely, putamen and M1 versus posterior superior temporal lobe, respectively). The putamen seed showed reduced connectivity within the basal ganglia in patients for both lexical categories. However, only action verbs recruited different cortical networks in each group. Specifically, the M1 seed exhibited more anterior connectivity for controls and more posterior connectivity for patients, with no differences in the temporal seed. Moreover, the patients´ level of basal ganglia atrophy positively correlated with their reliance on M1-posterior connectivity during action-verb processing. PD patients seem to have processed action verbs via non-motor cortical networks subserving amodal semantics. Such circuits may afford alternative pathways to process words when default embodied mechanisms are disturbed. Moreover, the greater the level of basal ganglia atrophy, the greater the patients´ reliance on this alternative route. These results offer new insights into differential neurofunctional mechanisms recruited to process action semantics in PD.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
IOS Press  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Functional Magnetic Resonance Imaging  
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Parkinson'S Disease  
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Language  
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Motor Cortex  
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Semantics  
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Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
The Road Less Traveled: Alternative Pathways for Action-Verb Processing in Parkinson’s Disease  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
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info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-06T20:46:47Z  
dc.journal.volume
55  
dc.journal.number
4  
dc.journal.pagination
1429-1435  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Abrevaya, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina  
dc.description.fil
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina  
dc.description.fil
Fil: Fittipaldi, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina  
dc.description.fil
Fil: Pineda, David. Universidad de Antioquia; Colombia  
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Fil: Lopera, Francisco. Universidad de Antioquia; Colombia  
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Fil: Buritica, Omar. Universidad de Antioquia; Colombia. Neurology Unit Pablo Tobon Uribe Hospital; Colombia  
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Fil: Villegas, Andrés. Universidad de Antioquia; Colombia  
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Fil: Bustamante, Catalina. Instituto de Alta Tecnología Médica de Antioquia; Colombia  
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Fil: Gomez, Diana. Universidad de Antioquia; Colombia  
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Fil: Trujillo, Natalia. Universidad de Antioquia; Colombia  
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Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina  
dc.description.fil
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council; Australia  
dc.description.fil
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo; Argentina  
dc.journal.title
Journal of Alzheimer's Disease  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.3233/JAD-160737  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160737