Artículo
Abscopal effect of boron neutron capture therapy (BNCT): proof of principle in an experimental model of colon cancer
Trivillin, Verónica Andrea
; Pozzi, Emiliano César Cayetano; Colombo, Lucas Luis
; Thorp, Silvia Inés; Garabalino, Marcela Alejandra; Monti Hughes, Andrea
; González, Sara Josefina
; Farías, Rubén Oscar
; Curotto, Paula; Santa Cruz, Gustavo Alberto; Carando, Daniel Germán
; Schwint, Amanda Elena
Fecha de publicación:
08/2017
Editorial:
Springer
Revista:
Radiation and Environmental Biophysics
ISSN:
0301-634X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The aim of the present study was to evaluate, for the first time, the abscopal effect of boron neutron capture therapy (BNCT). Twenty-six BDIX rats were inoculated subcutaneously with 1 × 106 DHD/K12/TRb syngeneic colon cancer cells in the right hind flank. Three weeks post-inoculation, the right leg of 12 rats bearing the tumor nodule was treated with BPA-BNCT (BPA-Boronophenylalanine) at the RA-3 nuclear reactor located in Buenos Aires, Argentina, at an absorbed dose of 7.5 Gy to skin as the dose-limiting tissue. The remaining group of 14 tumor-bearing rats were left untreated and used as control. Two weeks post-BNCT, 1 × 106 DHD/K12/TRb cells were injected subcutaneously in the contralateral left hind flank of each of the 26 BDIX rats. Tumor volume in both legs was measured weekly for 7 weeks to determine response to BNCT in the right leg and to assess a potential influence of BNCT in the right leg on tumor development in the left leg. Within the BNCT group, a statistically significant reduction was observed in contralateral left tumor volume in animals whose right leg tumor responded to BNCT (post-treatment/pre-treatment tumor volume <1) versus animals who failed to respond (post/pre ≥1), i.e., 13 ± 15 vs 271 ± 128 mm3. In addition, a statistically significant reduction in contralateral left leg tumor volume was observed in BNCT-responsive animals (post/pre <1) vs untreated animals, i.e., 13 ± 15 vs 254 ± 251 mm3. The present study performed in a simple animal model provides proof of principle that the positive response of a tumor to BNCT is capable of inducing an abscopal effect.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Trivillin, Verónica Andrea; Pozzi, Emiliano César Cayetano; Colombo, Lucas Luis; Thorp, Silvia Inés; Garabalino, Marcela Alejandra; et al.; Abscopal effect of boron neutron capture therapy (BNCT): proof of principle in an experimental model of colon cancer; Springer; Radiation and Environmental Biophysics; 56; 4; 8-2017; 365-375
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