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dc.contributor.author
Marchese, Natalia Andrea
dc.contributor.author
Paz, Maria Constanza
dc.contributor.author
Caeiro, Ximena Elizabeth
dc.contributor.author
Dadam, Florencia Maria
dc.contributor.author
Baiardi, Gustavo Carlos
dc.contributor.author
Perez, Mariela Fernanda
dc.contributor.author
Bregonzio Diaz, Claudia
dc.date.available
2018-06-08T14:46:09Z
dc.date.issued
2017-01
dc.identifier.citation
Marchese, Natalia Andrea; Paz, Maria Constanza; Caeiro, Ximena Elizabeth; Dadam, Florencia Maria; Baiardi, Gustavo Carlos; et al.; Angiotensin II AT1 receptors mediate neuronal sensitization and sustained blood pressure response induced by a single injection of amphetamine; Pergamon-Elsevier Science Ltd; Neuroscience; 340; 1-2017; 521-529
dc.identifier.issn
0306-4522
dc.identifier.uri
http://hdl.handle.net/11336/47846
dc.description.abstract
A single exposure to amphetamine induces neurochemical sensitization in striatal areas. The neuropeptide angiotensin II, through AT1 receptors (AT1-R) activation, is involved in these responses. However, amphetamine-induced alterations can be extended to extrastriatal areas involved in blood pressure control and their physiological outcomes. Our aim for the present study was to analyze the possible role for AT1-R in these events using a twoinjection protocol and to further characterize the efficacy of the proposed AT1-R antagonism protocol. Central effect of orally administered AT1-R blocker (3mg/kg p.o. × 5 days) was analyzed recording spontaneous activity of the locus coeruleus. In another group of animals, pretreated with AT1-R blocker or vehicle, sensitization was achieved by a single administration of amphetamine (5mg/kg i.p- day 6) followed by a 3 week period off drug. After receiving an amphetamine challenge (0.5mg/kg i.p), we evaluated: 1) the sensitized cFos expression in locus coeruleus (LC), nucleus of the solitary tract (NTS), caudal ventrolateral medulla (A1) and central amygdala (CeAmy); and 2) the blood pressor response. AT1-R blockade decreased LC neurons? spontaneous firing rate. Moreover, sensitized c-Fos immunoreactivity was found in LC and NTS; and both responses were blunted by the AT1-R blocker pretreatment. Meanwhile, no differences were found neither in CeAmy nor A1. Sensitized pressor response was observed as sustained changes in mean arterial pressure and was effectively prevented by AT1-R blockade. Our results support the important role for brain AT1-R in amphetamine-induced sensitization, this time in extra-striatal areas and over its physiological outcome.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Angiotensin Ii
dc.subject
At1 Receptors
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Amphetamine Sensitization
dc.subject
Blood Pressure Response
dc.subject.classification
Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Angiotensin II AT1 receptors mediate neuronal sensitization and sustained blood pressure response induced by a single injection of amphetamine
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-29T20:57:12Z
dc.journal.volume
340
dc.journal.pagination
521-529
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Marchese, Natalia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Paz, Maria Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Caeiro, Ximena Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Dadam, Florencia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
dc.description.fil
Fil: Perez, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.journal.title
Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuroscience.2016.11.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306452216306194


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