Artículo
Paclitaxel: What has been done and the challenges remain ahead
Bernabeu, Ezequiel Adrian
; Cagel, Carlos Maximiliano
; Lagomarsino, Eduardo; Moretton, Marcela Analía
; Chiappetta, Diego Andrés
Fecha de publicación:
06/2017
Editorial:
Elsevier Science
Revista:
International Journal Of Pharmaceutics
ISSN:
0378-5173
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In recent years, the nanotechnology has offered researchers the opportunity to solve the problems caused by the vehicle of the standard and first formulation of paclitaxel (Taxol), while maximizing the provenantineoplastic activity of the drug against many solid tumors. Hence, different types of nanocarriers have been employed to improve the efficacy, safety, physicochemical properties and pharmacokinetic/pharmacodynamic profile of this drug. To date, paclitaxel is the unique drug that is marketed in three different nanoplatforms for its parenteral delivery: polymeric nanoparticles (Abraxane), liposomes (Lipusu), and polymeric micelles (Genexol, Nanoxel and Paclical). Indeed, a fourth nanocarrier might be available soon, because phase III studies of OpaxioTM, a polymeric-conjugated, are near completion. Furthermore, other several nanoformulations are currently in various stages of clinical trials. Therefore, it is only through the critical analysis of clinical evidence from these studies that we can get a more concrete idea of what has been achieved with pharmaceutical nanotechnology so far. This review attempts to summarize current information available regarding the clinical status and the physicochemical characteristic of different nanocarriers for paclitaxel delivery in cancer therapy. We present an overview of the preclinical and clinical data of these systems including their pharmacokinetics, dose and administration, adverse events and clinical efficacy.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Bernabeu, Ezequiel Adrian; Cagel, Carlos Maximiliano; Lagomarsino, Eduardo; Moretton, Marcela Analía; Chiappetta, Diego Andrés; Paclitaxel: What has been done and the challenges remain ahead; Elsevier Science; International Journal Of Pharmaceutics; 526; 1-2; 6-2017; 474-495
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