Artículo
Polymeric mixed micelles as nanomedicines: Achievements and perspectives
Cagel, Carlos Maximiliano
; Tesan, Fiorella Carla; Bernabeu, Ezequiel Adrian
; Salgueiro, María Jimena; Zubillaga, Marcela Beatriz
; Moretton, Marcela Analía
; Chiappetta, Diego Andrés
Fecha de publicación:
04/2017
Editorial:
Elsevier Science
Revista:
European Journal Of Pharmaceutics And Biopharmaceutics
ISSN:
0939-6411
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
During the past few decades, polymeric micelles have raised special attention as novel nano-sized drug delivery systems for optimizing the treatment and diagnosis of numerous diseases. These nanocarriers exhibit several in vitro and in vivo advantages as well as increased stability and solubility to hydrophobic drugs. An interesting approach for optimizing these properties and overcoming some of their disadvantages is the combination of two or more polymers in order to assemble polymeric mixed micelles. This review article gives an overview on the current state of the art of several mixed micellar formulations as nanocarriers for drugs and imaging probes, evaluating their ongoing status (preclinical or clinical stage), with special emphasis on type of copolymers, physicochemical properties, in vivo progress achieved so far and toxicity profiles. Besides, the present article presents relevant research outcomes about polymeric mixed micelles as better drug delivery systems, when compared to polymeric pristine micelles. The reported data clearly illustrates the promise of these nanovehicles reaching clinical stages in the near future.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Cagel, Carlos Maximiliano; Tesan, Fiorella Carla; Bernabeu, Ezequiel Adrian; Salgueiro, María Jimena; Zubillaga, Marcela Beatriz; et al.; Polymeric mixed micelles as nanomedicines: Achievements and perspectives; Elsevier Science; European Journal Of Pharmaceutics And Biopharmaceutics; 113; 4-2017; 211-228
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