Artículo
High virulence of methicillin resistant Staphylococcus aureus ST30-SCC mec IVc- spa t019, the dominant community-associated clone in Argentina
Fernández, Silvina; Ledo, Camila
; Lattar, Santiago Martín
; Noto Llana, Mariangeles
; Mendoza Bertelli, Andrea Cristina
; Di Gregorio, Sabrina Noelia
; Sordelli, Daniel Oscar
; Gomez, Marisa Ines
; Mollerach, Marta Eugenia
Fecha de publicación:
06/2017
Editorial:
Elsevier Gmbh
Revista:
International Journal of Medical Microbiology (print)
ISSN:
1438-4221
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Community-acquired methicillin resistant Staphylococcus aureus emerged as a worldwide health problem in the last few years. In Argentina, it is found in 70% of skin and skin structure infections in previously healthy adult patients and causes severe invasive diseases. The ST30-SCCmecIVc-spat019 clone is predominant in adult infections and has displaced the previously prevalent ST5-SCCmecIVa-spat311 clone in community settings. In the present work we compared the virulence of both clones in order to explain the displacement, and found that ST30-IVc is associated with invasive infections in adult patients from Argentina and possesses a different virulence-associated genes profile compared to ST5-IVa. A representative strain of ST30 lineage has a more aggressive behavior in animal models of infection and expresses higher level of Fibronectin binding protein A coding gene, which could enhance the bacterial invasion capacity.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Fernández, Silvina; Ledo, Camila; Lattar, Santiago Martín; Noto Llana, Mariangeles; Mendoza Bertelli, Andrea Cristina; et al.; High virulence of methicillin resistant Staphylococcus aureus ST30-SCC mec IVc- spa t019, the dominant community-associated clone in Argentina; Elsevier Gmbh; International Journal of Medical Microbiology (print); 307; 4-5; 6-2017; 191-199
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