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dc.contributor.author
Moretton, Marcela Analía
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Bertera, Facundo Martin
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Lagomarsino, Eduardo
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Riedel, Jennifer Denise
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Chiappetta, Diego Andrés
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Höcht, Christian
dc.date.available
2018-06-07T20:18:11Z
dc.date.issued
2017-04
dc.identifier.citation
Moretton, Marcela Analía; Bertera, Facundo Martin; Lagomarsino, Eduardo; Riedel, Jennifer Denise; Chiappetta, Diego Andrés; et al.; Advances in therapy for the prevention of HIV transmission from mother to child; Informa Healthcare; Expert Opinion on Pharmacotherapy; 18; 7; 4-2017; 657-666
dc.identifier.issn
1465-6566
dc.identifier.uri
http://hdl.handle.net/11336/47775
dc.description.abstract
Introduction: Actually, ~17.8 million women and 1.8 million children (<15 years) are currently infected with the Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS). Particularly, the majority of pediatric infections (>90%) resulted from ‘HIV mother-to-child transmission’ (MTCT), both in pregnancy, labour, delivery and later by breastfeeding. Due to its high pediatric incidence, MTCT represents a public health concern. 15 Areas covered: In this review, we focus on available treatments and antiretroviral drugs recommended by the World Health Organization, and the main clinical investigations in antiretroviral pharmacotherapy to prevent the MTCT. Expert opinion: The MTCT has been improved dramatically in the last few years mainly due to prophylactic perinatal antiretroviral therapy for pregnant women living with HIV. However, there is 20 still a milestone to reach since HIV MTCT remains as a public health challenge associated with MTCT though breastfeeding (post-natal transmission). In this context, different strategies could be employed as an attempt to reduce pediatric HIV infections. One of them involves the improvement of patient adherence to the HIV therapy. One possible solution is the development of novel long-acting formulations for prophylaxis of mothers and children, and a second possible solution is increase the inclusion of 25 mothers and infants in care programs to more effectively prevent the vertical transmission.
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application/pdf
dc.language.iso
eng
dc.publisher
Informa Healthcare
dc.rights
info:eu-repo/semantics/openAccess
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hiv Mother-To-Child Transmission
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Antiretroviral Pharmacotherapy
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Prevention
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Pregnancy
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Breastfeeding
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Advances in therapy for the prevention of HIV transmission from mother to child
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-07T14:25:42Z
dc.journal.volume
18
dc.journal.number
7
dc.journal.pagination
657-666
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Moretton, Marcela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Bertera, Facundo Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Lagomarsino, Eduardo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Riedel, Jennifer Denise. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
Expert Opinion on Pharmacotherapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1080/14656566.2017.1316369
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/14656566.2017.1316369
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