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dc.contributor.author
Cheung, Leonard Y. M.
dc.contributor.author
Davis, Shannon W.
dc.contributor.author
Brinkmeier, Michelle L.
dc.contributor.author
Camper, Sally A.
dc.contributor.author
Pérez Millán, María Inés
dc.date.available
2018-06-07T19:46:06Z
dc.date.issued
2017-04
dc.identifier.citation
Cheung, Leonard Y. M.; Davis, Shannon W.; Brinkmeier, Michelle L.; Camper, Sally A.; Pérez Millán, María Inés; Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways; Elsevier Ireland; Molecular and Cellular Endocrinology; 445; 4-2017; 14-26
dc.identifier.issn
0303-7207
dc.identifier.uri
http://hdl.handle.net/11336/47759
dc.description.abstract
The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise from stem cells that express SOX2 and the pituitary transcription factor PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. The adult anterior pituitary responds to physiological challenge by mobilizing the SOX2-expressing progenitor pool and producing additional hormone-producing cells. Knowledge of the role of signaling pathways and extracellular matrix components in these processes may lead to improvements in the efficiency of differentiation of embryonic stem cells or induced pluripotent stem cells into hormone producing cells in vitro. Advances in our basic understanding of pituitary stem cell regulation and differentiation may lead to improved diagnosis and treatment for patients with hypopituitarism.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Emt
dc.subject
Prop1
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Sox2
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Pituitary
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Stem Cells
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Extracellular Matrix
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-06T13:37:45Z
dc.identifier.eissn
1872-8057
dc.journal.volume
445
dc.journal.pagination
14-26
dc.journal.pais
Irlanda
dc.journal.ciudad
Shannon
dc.description.fil
Fil: Cheung, Leonard Y. M.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Davis, Shannon W.. University of South Carolina; Estados Unidos
dc.description.fil
Fil: Brinkmeier, Michelle L.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Camper, Sally A.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Pérez Millán, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
Molecular and Cellular Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.mce.2016.09.016
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720716303811
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590650/
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