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dc.contributor.author
Del Rey, Adriana
dc.contributor.author
Randolf, Anke
dc.contributor.author
Pitossi, Fernando Juan
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dc.contributor.author
Rogausch, Heiner
dc.contributor.author
Besedovsky, Hugo O.
dc.date.available
2018-06-07T18:59:17Z
dc.date.issued
2006-01
dc.identifier.citation
Del Rey, Adriana; Randolf, Anke; Pitossi, Fernando Juan; Rogausch, Heiner; Besedovsky, Hugo O.; Not All Peripheral Immune Stimuli That Activate the HPA Axis Induce Proinflammatory Cytokine Gene Expression in the Hypothalamus; Blackwell Publishing; Annals of the New York Academy of Sciences; 917; 1; 1-2006; 169-174
dc.identifier.issn
0077-8923
dc.identifier.uri
http://hdl.handle.net/11336/47746
dc.description.abstract
Administration of low doses of lipopolysaccharide (LPS) that do not disrupt the blood-brain barrier (BBB) results in the expression of interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF alpha) in the hypothalamus in parallel to stimulation of the hypothalamus-pituitary-adrenal (HPA) axis. This endocrine response is triggered by peripheral cytokines, and we recently obtained evidence that brain-borne IL-1 contributes to its maintenance. LPS preferentially stimulates cells of the macrophage lineage and B lymphocytes. The possibility that primarily stimulation of other types of peripheral immune cells also results in the expression of proinflammatory cytokines in the brain and in the activation of the HPA axis was investigated. Our results showed that, in contrast to LPS, administration of the superantigen staphylococcal enterotoxin B (SEB), which stimulates T cells by binding to appropriate V beta domains of the T-cell receptor, did not result in induction of IL-1 beta, IL-6, and TNF alpha expression in the hypothalamus. Furthermore, although IL-2 transcripts in the spleen were highly increased, expression of this gene was not detected in the brain. However, as with LPS, SEB administration also results in elevated levels of glucocorticoids in blood. Therefore, our data suggest that increased expression of proinflammatory cytokines in the brain is not a necessary step in the stimulation of the HPA axis by SEB.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Blackwell Publishing
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Microglial Cells
dc.subject
Lps
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Not All Peripheral Immune Stimuli That Activate the HPA Axis Induce Proinflammatory Cytokine Gene Expression in the Hypothalamus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-10T15:45:47Z
dc.identifier.eissn
1749-6632
dc.journal.volume
917
dc.journal.number
1
dc.journal.pagination
169-174
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Oxford
dc.description.fil
Fil: Del Rey, Adriana. Philipps University; Alemania
dc.description.fil
Fil: Randolf, Anke. Philipps University; Alemania
dc.description.fil
Fil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Rogausch, Heiner. Philipps University; Alemania
dc.description.fil
Fil: Besedovsky, Hugo O.. Philipps University; Alemania
dc.journal.title
Annals of the New York Academy of Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2000.tb05381.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/j.1749-6632.2000.tb05381.x
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